Introduction:Radiation exposure poses hazards for health-care providers as well as patients in health-care facilities (HCFs). Radiographic imaging is extremely valuable as a diagnostic tool in medicine, but ionizing radiation and computed tomography (CT) scan carry well-known potential risks. Personnel and radiation safety monitoring is an important safety precaution in the practice of radiography.Aim:The study aimed to assess the occupational radiation exposure and safety protection among medical staff in HCFs in the Eastern Province, Kingdom of Saudi Arabia (KSA).Materials and Methods:Total of 4 HCFs with radiological services were randomly selected for the study in the period from January to April 2013. The radiation survey has been carried out by the measurement of radiation in the x-ray and CT-scan room at different points of the diagnostic, imaging, and waiting rooms of different hospitals. The radiation safety was assessed by using a questionnaireResults:The results of our study are surprising and alarming. Data revealed that there are a significant association between the levels of radiation exposure in all selected hospitals concerning imaging and waiting X-ray and CT-scan operating room (P < 0.01). For radiation safety, most hospitals have lead aprons and thyroid shields in place, but only about 50% have lead glasses and lead shields, showing that many hospitals still lack essential equipment. Moreover, actual utilization rate of radiation dosimeters are 57.7% and 68.9%, respectively.Conclusion:All medical staff as well as patients are at risk of exposure to x-ray and CT-scan radiation exposure, and the levels are exceeding the standard guidelines. Many hospitals still lack safety protection tools and there is a complete absence of radiation protection equipment. Further studies should be conducted to highlight different aspects of radiation exposure dose and safety protection tools.
Date fruits have ample amount of beneficial minerals but owing to diverse causes may contract with heavy metals and contaminants during field, processing, or transportation posing health challenges to consumers. Hence, current research explored the toxic heavy metals (Al, As, Cr, Pb, Cd, and Sb) levels in seven date varieties (Sakay Mabroum, Sakay Normal, Rashadya Al-qaseem, Barny Al-Madina, Eklas Al-Hassa, Safawy Al-Madina, Kadary) collected from different locations of Saudi Arabia by applying inductively coupled plasma optical emission spectroscopy. Mean values of heavy metals were calculated and expressed. Most of the heavy metals with the exception of As, Pb, and Cd are within safe limit with respect to maximum allowable levels (MAL) in some date cultivars. Estimated daily intake (EDI) of heavy metals through dates consumption (100 gram/person/day) for As and Pb exceeded the Provisional maximum tolerable daily intake from some locations. Although Cd content was exceeding MAL; however, its EDI is well within safe limits of Provisional maximum tolerable daily intake. From EDI data, hazard risk index was also calculated, which predicted that both As and Pb can pose potential health hazards to dates consumers in Saudi Arabia. However, Pb contributed greater health risks due to date fruit consumption as compared to Arsenic.
BackgroundLead (Pb) is a persistent environmental neurotoxin and its exposure even in minute quantities has been known to induce neuronal defects. The immature brain is singularly sensitive to Pb neurotoxicity, and its exposure during development has permanent detrimental effects on the brain developmental trajectory and neuronal signaling and plasticity, culminating into compromises in the cognitive and behavioral attributes which persists even later in adulthood. Several molecular pathways have been implicated in the Pb-mediated disruption of neuronal signaling, including elevated oxidative stress, alterations in neurotransmitter biology, and mitochondrial dysfunction. Nevertheless, the neuronal targets and biochemical pathways underlying these Pb-mediated alterations in synaptic development and function have not been completely deduced. In this respect, recent studies have shown that synaptic signaling and its maintenance and plasticity are critically dependent on localized de novo protein translation at the synaptic terminals.Materials and methodsThe present study hence aimed to assess the alterations in the synapse-specific translation induced by developmental Pb exposure. To this end, in vitro protein translation rate was analyzed in the hippocampal synaptoneurosomal fractions of rat pups pre- and postnatally exposed to Pb using a puromycin incorporation assay. Moreover, we evaluated the therapeutic effects of ascorbic acid supplementation against Pb-induced deficits in synapse-localized protein translation.ResultsWe observed a significant loss in the rates of de novo protein translation in synaptoneurosomes of Pb-exposed pups compared to age-matched control pups. Interestingly, ascorbate supplementation lead to an appreciable recovery in Pb-induced translational deficits. Moreover, the deficit in activity-dependent synaptic protein translation was found to correlate significantly with the increase in the blood Pb levels.ConclusionDysregulation of synapse-localized de novo protein translation is a potentially critical determinant of Pb-induced synaptic dysfunction and the consequent deficits in behavioral, social, and psychological attributes of the organisms. In addition, our study establishes ascorbate supplementation as a key ameliorative agent against Pb-induced neurotoxicity.
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