A new series of spiro 1,2,4-triazoles 5-9a-j were prepared by the reaction of appropriate amidrazones 4 with cyclic ketones in catalytic amount of p-toluene sulfonic acid. The structures of the titled compounds have been elucidated by the elemental analysis and spectroscopic data (IR, 1 H NMR, 13 C NMR and MS). The biological activities of the prepared compounds were investigated using well-established methods from the literature.
A series of new spiro 1,2,4-triazoles V-IXa-j were synthesized by the reaction of appropriate amidrazones IV with cyclic ketones in the presence of p-toluene sulfonic acid as a catalyst. The structures of the synthesized compounds have been confirmed by the elemental analysis and spectroscopic data (IR, 1H NMR, 13C NMR and MS). The microbial features of the synthesized compounds were studied using well-established methods from the literature.
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