Purpose This study purposed to assess the psychosocial correlates of work‐related fatigue among Jordanian emergency department nurses. Design and Methods A cross‐sectional study was conducted among Jordanian emergency nurses (n = 220). Measures included Occupational Fatigue Exhaustion/Recovery Scale (OFER15) and Copenhagen Psychosocial Questionnaire version Two (COPSOQ II). Findings The psychosocial factors correlated with all types of work‐related fatigue (acute, chronic, and inter‐shift [recovery]) were quantitative demands, work‐family conflict, sexual harassment, threats of violence, physical violence, and bullying. Importantly, quantitative demands and sexual harassment were the main predictors of all types of work‐related fatigue. Practice Implications The psychosocial correlated factors should be considered when developing interventions to minimize work‐related fatigue phenomenon. This would lead to a more positive working environment which will promote safe nursing care.