Changes in blood sugar in poisoning can be one of the most important determinants of the outcome of patients with poisoning. Since poisoning is one of the most common and increasing causes of death worldwide and one of the most critical medical emergencies, this study aimed to investigate changes in blood sugar in patients with acute poisoning and how patients' blood sugar can predict the severity and outcome of the disease. The present study was performed on 200 patients with acute drug poisoning referred to the emergency department of Amir Al-Momenin Hospital in Zabol from March 2018 to March 2020. Blood glucose levels of all patients were recorded at the time of admission and every hour to the first 5 hours after admission, and the results were entered in the information form of each patient. Finally, the data were entered into SPSS V22 software and statistically analyzed. The mean age of participants was 23.21 ± 12.80 years, and the minimum and maximum age of patients were 1 year and 77 years, respectively, and only 9.8% of them had a history of diabetes. In this study, the highest rate of intoxication with opioids such as methadone and tramadol was (38%), followed by benzodiazepines (20.5%), NSAIDs (19.5%), and SSRIs (7%) were the most commonly used drugs. The prevalence of hypoglycemia in this study was 3% (6 patients), while no cases of hyperglycemia were reported. In this study, most changes in blood sugar were caused by alcohol poisoning. Also, neuroleptics, NSAIDs, and chemicals had the least changes in blood sugar. However, patients' blood sugar at the beginning of poisoning did not affect patients' prognosis. The present study results showed that changes in blood sugar during treatment during drug intoxication, alcohol, medications(sulfonylurea, glibenclamide), and NSAID are very important, so regular monitoring of blood glucose in intoxication with these cases is essential.
INTRODUCTION: Metastatic or recurrent colorectal cancer (MRCRC) has a poor prognosis. The aim of the present meta-analysis was to assess the prevalence of different subtypes of KRAS mutation and BRAF mutation in metastatic CRC patients, and evaluate the relationship between the tumor sidedness and prevalence of KRAS and BRAF mutation. METHODS: We searched MEDLINE/PubMed, the Cochrane Library, and ClinicalTrials.gov from January 2010 to July 2020. The data were extracted independently according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The statistical analysis was done using STATA and Meta-Disk 1.4 applications. RESULTS: Overall, 6699 colorectal cancer patients were included. KRAS and BRAF mutation was reported in 28% and 6% of patients, respectively. The overall prevalence of right primary and left primary metastatic CRC patients with mutated KRAS was 40% and 60%. However, the prevalence BRAF mutated right primary and left primary metastatic CRC patients was 37% and 63%. The overall HR was 2.38 for patients with metastatic CRC who had a mutated type of KRAS. Our study showed a mean overall survival of 35.4 month for KRAS mutant and a 10.12 month survival for BRAF mutant patients with metastatic colorectal cancer patients. CONCLUSION: The prevalence of KRAS and BRAF mutations varied significantly according to the location of the tumor. BRAF mutations are more commonly found in metastatic colorectal cancers on the right side. Liver was the most common site of metastases in patients with mutant KRAS and the mortality of patients with mutant KRAS was 2.3 times higher than the patients with wild types. These results help to better describe the population of mCRC patients and can have implications for improving and organizing anti-EGFR therapies. Further research is needed to assess differences in survival through mutation status and primary tumor location.
: In December 2019, a cluster of pneumonia cases, caused by a newly identified coronavirus, occurred in Wuhan, China, named COVID-19 by the World Health Organization (WHO). We present a 60-year-old woman with a four-day history of headache, myalgia, and weakness. She reported no shortness of breath or chest pain. Her blood pressure was 15/6 mmHg, and she had a history of hypertension. The laboratory tests showed only thrombocytopenia with a platelet count of 30 × 109 /L, and chest CT showed bilateral ground-glass opacities, so she received treatment with three drugs. One day after recovery and discharge from the hospital, she suffered cardiopulmonary arrest at home. Patients with cardiovascular disease are at a higher risk of COVID-19 infection. Therefore, it is necessary to pay particular attention to cardiac injuries caused by viral infections both during and after the treatment of these patients.
Background: This study aimed to evaluate the diagnostic accuracy of [ 18 F]FDG PET/MR versus [ 18 F]FDG PET/CT in the thoracic staging of patients with non-small cell lung cancer (NSCLS). Material and methods:The Preferred Reporting Items for Systematic Reviews (PRISMA) were followed in conducting the present study. All available research was collected through Embase (Elsevier), PubMed, as well as Cochrane Library databases up to June 2021. Only studies covering both [ 18 F]FDG PET/MRI and [ 18 F]FDG PET/CT techniques in the same group were included.Statistical analysis was done using Stata v.12.
The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. This study aimed to investigate the association between IL23R 1142 G/A (Arg381Gln) and GM-CSF 3928 C/T (Ile117Thr) gene polymorphisms with the incidence rate of tuberculosis in the population of Sistan. This study was based on the descriptive and applied type. All patients with active pulmonary tuberculosis were referred to the tuberculosis center of Zabol city for one year, with an equal number of healthy people adapted to the patients examined in terms of age. After data collecting to compare the frequency of polymorphisms, the chisquare test and OR index were used using SPSS software version 16. We have found that the IL23R reduced-function allele 1142A and genotypes CC and TC were overrepresented, especially in the Pad subgroup compared with the control group (44% versus 42%, 21% versus 22%, and 44% versus 39%, respectively. Increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G ¡ A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in ZABOL patients. The genotypic and allelic frequency of IL23R 1142 G/A, and GM-CSF 3928 C/T (Ile117Thr) polymorphism in patients with tuberculosis was significantly different from the control group and this polymorphism was associated with the incidence of tuberculosis in the population of Sistan.
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