A new set of 4,6,7,8-tetrahydroquinolin-5(1H)-ones were designed as cytotoxic agents against breast cancer cell line (MCF-7) and synthesised under ultrasonic irradiation using chitosan decorated copper nanoparticles (CS/CuNPs) catalyst. The new compounds 4b, 4j, 4k, and 4e exhibited the most potent cytotoxic activity of IC 50 values (0.002 À 0.004 mM) comparing to Staurosporine of IC 50 ; 0.005 lM. The latter derivatives exhibited a promising safety profile against the normal human WI38 cells of IC 50 range 0.0149 À 0.048 mM. Furthermore, the most promising cytotoxic compounds 4b, 4j were evaluated as multitargeting agents against the RTK protein kinases; EGFR, HER-2, PDGFR-b, and VEGFR-2. Compound 4j showed promising inhibitory activity against HER-2 and PDGFR-b of IC 50 values 0.17 Â 10 À3 , 0.07 Â 10 À3 mM in comparison with the reference drug sorafenib of IC 50 ; 0.28Â 10 À3 , 0.13 Â 10 À3 mM, respectively. In addition, 4j induced apoptotic effect and cell cycle arrest at G2/M phase preventing the mitotic cycle in MCF-7 cells.
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