Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare condition affecting between 1 in 1,000 to 1 in 10,000 patients after exposure to associated drugs. [1] It is a life-threatening condition with a mortality rate of about 10%, which necessitates early identification and treatment. [2] We describe a case of DRESS syndrome secondary to the use of chlorpromazine in a female with paranoid schizophrenia, the diagnostic challenge encountered, and the successful treatment of the condition with corticosteroids. Financial support and sponsorship Nil.
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