tolerance in children. We performed a systematic search of the databases PubMed, Pediatrics Pulmonology, European journal of paediatrics, chest physician and Cochrane review for last 5 years. Method Thirteen clinical studies and Randomized control trials which were done on children treated with hypertonic saline with bronchiolitis hospitalised in an emergency department and general ward were included from year 2014-2019. We included 8 RCT, 1 meta-analysis, 1 Cochrane or 1 decision analysis and 2 Trial sequential analysis and excluded the studies/trials included in Cochrane review 2017 and Meta-analysis 2018. Main outcome of 8 trial out of these 13 trials was 'Length of stay(LOS)' in hospital and 'admission rate' was studied in 1 of these.1 trial used 'fit for discharge' as main outcome in their trial and 2 Trials looked at the cost effectiveness of use of HS in bronchiolitis. Results The available studies suggest that Hypertonic saline is promising and safe to use in children with bronchiolitis but there is no superiority found when compared with NS or standard care in reducing the length of hospital stay or admission from emergency department. Conclusion Hypertonic saline is safe to use in children with bronchiolitis but there is no extra benefit of it in reducing the disease severity, admissions rate or length of stay.
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