Objectives:The present study aimed to evaluate the bond strength of heat-cure denture base resin to newly designed Iranian artificial acrylic teeth.Materials and Methods:In this in-vitro experimental study, shear bond strengths of Ivoclar acrylic, Apple composite, and B-Star nanocomposite teeth to heat-cure acrylic denture base resin were compared. A total of 18 samples were selected from each group of teeth. The samples were attached to heat-cure resin according to ISO 10477 standard. For the assessment of bond strength, the samples were placed in a universal testing machine and were subjected to shear forces at a speed of 1 mm/minute to record the fracture load. Descriptive statistics, including frequency, mean, and standard deviation, were calculated using SPSS 20 software. Two-way analysis of variance was used to compare the shear bond strength of the groups with and without monomers and the studied artificial teeth.Results:The mean shear bond strengths of Ivoclar acrylic teeth were 392.22±23.76 MPa and 337.11±32.18 MPa with and without adding monomers to the tooth surface, respectively. The mean shear bond strengths were 250.44±29.84 MPa and 238.33±27.28 MPa (without monomers) and 438.33±24.16 MPa and 311.56±32.78 MPa (with monomers) for Apple composite and B-Star nanocomposite artificial teeth, respectively.Conclusion:The greatest shear bond strength was attributed to Ivoclar acrylic teeth followed by Apple composite and B-Star nanocomposite artificial teeth. Addition of monomers to the tooth surface significantly strengthened the shear bonding of acrylic base resin to the teeth.