A 65-year-old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second-line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole-based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.
Abstract. A non-typeable Haemophilus influenzae (NTHi) was responsible for an invasive infection including bacteremia, spondylodiscitis with epidural abscess, and periprosthetic hip
infection in a 79-year-old woman, triggered by a superinfected ethmo-orbital
mucocele. Surgical drainage and antibiotic therapy allowed recovery.
PET-scan full cartography of NTHi infection dissemination enabled the
discovery of spondylodiscitis. This rare cause of spondylodiscitis and
periprosthetic joint infection suggests a complete work-up is unavoidable.
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