Type 2 diabetes is characterized partially by elevated fasting blood serum glucose and insulin concentrations and the percentage of hemoglobin as HbA1c. It was hypothesized that each of blood glucose and its co-factors insulin and HbA1c and would show a more favorable profile as the result of flaxseed oil supplementation. Patients were recruited at random from a population pool responding to a recruitment advertisement in the local newspaper and 2 area physicians. Completing the trial were 10 flaxseed oil males, 8 flaxseed oil females, 8 safflower (placebo) oil males and 6 safflower oil females. Patients visited on two pre-treatment occasions each three months apart (visits 1 and 2). At visit 2 subjects were randomly assigned in double blind fashion and in equal gender numbers to take flaxseed oil or safflower oil for three further months until visit 3. Oil consumption in both groups was ~ 10 g/d. ALA intake in the intervention group was ~ 5.5 g/d. Power was 0.80 to see a difference of 1 mmol of glucose /L using 12 subjects per group with a p < 0.05. Flaxseed oil had no impact on fasting blood serum glucose, insulin or HbA1c levels. It is concluded that high doses of flaxseed oil have no effect on glycemic control in type 2 diabetics.
Hypothyroidism is one of the most common chronic endocrine conditions. However, as symptoms of hypothyroidism are non-specific, up to 60% of those with thyroid dysfunction are unaware of their condition. Left untreated, hypothyroidism may contribute to other chronic health conditions. In the Arabian Gulf States, hypothyroidism is thought to be common, but is underdiagnosed, and management approaches vary. An advisory board of leading Saudi endocrinologists and policy advisers was convened to discuss and formulate recommendations for the diagnosis and management of hypothyroidism in Saudi Arabia based on their clinical expertise. The final document was shared with leading endocrinologists from the other Gulf Cooperation Council (GCC) and aconsensus report was generated and summerized in this article. While there is no consensus Digital Features To view digital features for this article go to
BACKGROUNDThere are conflicting results on published randomized controlled trials (RCTs) on the role of vitamin E in the prevention of cancer. We conducted a meta-analysis of RCTs to evaluate the role of vitamin E in the prevention of cancer in adults.METHODSWe included RCTs in which the outcomes of the intake of vitamin E supplement alone or with other supplements were compared to a control group. The primary outcomes were total mortality, cancer mortality, total incidence of cancer, and incidence of lung, stomach, esophageal, pancreatic, prostate, breast and thyroid cancers. All identified trials were reviewed independently by the two reviewers to determine whether trials should be included or excluded. The quality of all included studies was scored independently by the two reviewers.RESULTSTwelve studies, which included 167 025 participants, met the inclusion criteria. There were no statistically significant differences in total mortality (relative risk, 0.99; 95% CI 0.96–1.03), cancer incidence (odds ratio, 0.96; 95% CI 0.92–1.01), and cancer mortality (odds ratio, 1.00; 95% CI, 0.96–1.03) among the different groups of patients included in this meta-analysis. Vitamin E was associated with a significant reduction in the incidence of prostate cancer (relative risk, 0.85; 95% CI, 0.73–0.96, number needed to treat=500), but it did not reduce the incidence of any other types of cancer.CONCLUSIONSVitamin E supplementation was not associated with a reduction in total mortality, cancer incidence, or cancer mortality, but it was associated with a statistically significant reduction in the incidence of prostate cancer. Vitamin E can be used in the prevention of prostate cancer in men who are at high risk of prostate cancer.
The obtained data indicate that high doses of flaxseed oil have no statistically significant effect on HOMA-IR or HOMA-%β in T2Ds, probably due to the additive effects of negative and positive correlations.
1017 Background: Several in vitro studies showed antioxidant vitamins to have a significant protective effect against cancer. We did a meta-analysis of Randomized Controlled Trials (RCTs) to evaluate the role of vitamin E supplements in the prevention of Cancer in adults Methods: We included RCTs, in which outcomes of the intake of vitamin E supplement alone or with other supplements, were compared to a control group.The primary outcomes were total mortality, cancer mortality, total incidence of Cancer, incidence of Lung, stomach, esophageal, pancreatic, prostate, breast and thyroid cancers. All identified trials were reviewed independently by the two reviewers to determine whether trials should be included or excluded. The quality of all included studies was scored independently by the two reviewers. RevMan, version 4.2 was used for the data analysis. Results: Twelve studies met inclusion criteria, including 167025 participants. There were no statistically significant differences in total mortality (RR 0.99; 95%CI 0.96–1.03), cancer incidence (OR 0.96; 95%CI 0.92, 1.01), and cancer mortality (OR 1.00; 95%CI 0.96–1.03) among the different groups of patients included in this meta-analysis. Vitamin E did not reduce the incidence of any type of cancer that was available for analysis; However there was a statistically significant reduction in the incidence of prostate cancer in patients receiving vitamin E, RR 0.85 [0.73–0.96, NNT=500]. Conclusions: Vitamin E supplementation was not associated with a reduction in total mortality or cancer incidence, and cancer mortality, but it was associated with a statistically significant reduction in the incidence of prostate cancer. Vitamin E can be used in the prevention of Prostate cancer in men who are at high risk of prostate cancer. No significant financial relationships to disclose.
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