The results showed efficacy, safety, predictability, and merits of LASIK and lens-based approaches for correcting different types of residual refractive error after cataract surgery.

Progressive loss of retinal ganglion cells (RGCs) leads to irreversible visual deficits in glaucoma. Here, we found that the level of cyclic AMP and the activity and expression of its mediator Epac1 were increased in retinas of two mouse models of ocular hypertension. Genetic depletion of Epac1 significantly attenuated ocular hypertension–induced detrimental effects in the retina, including vascular inflammation, neuronal apoptosis and necroptosis, thinning of ganglion cell complex layer, RGC loss, and retinal neuronal dysfunction. With bone marrow transplantation and various Epac1 conditional knockout mice, we further demonstrated that Epac1 in retinal neuronal cells (especially RGCs) was responsible for their death. Consistently, pharmacologic inhibition of Epac activity prevented RGC loss. Moreover, in vitro study on primary RGCs showed that Epac1 activation was sufficient to induce RGC death, which was mechanistically mediated by CaMKII activation. Taken together, these findings indicate that neuronal Epac1 plays a critical role in retinal neurodegeneration and suggest that Epac1 could be considered a target for neuroprotection in glaucoma.

BackgroundCosmetic contact lenses (CCL) are popular among adolescents, but incorrect use can harm the eye.MethodsThis study assessed CCL hygiene behaviors among adolescents attending a Texas pediatric clinic. Anonymous surveys about CCL hygiene practices were administered to adolescents 13–18 years old.ResultsWe found that 14% (53/392) of respondents had worn CCL, of which 83% were females. Over 70% reported first use at <15 years old. Knowledge about CCL was low and two-thirds of users had not been instructed on proper care. More than half stored them in water and did not rinse them with contact solution after removal. Over one-third wore CCL >8 hours/day. Moreover, 15% of CCL users reported borrowing someone else’s CCL. Complications resulting from wearing CCL were common.ConclusionThis study highlights poor CCL hygiene among adolescents. These data demonstrate the need to develop interventions to educate adolescents on proper care and risks associated with CCLs.

We report a case of late-onset diffuse lamellar keratitis (DLK) in the left eye of a 56-year-old white woman 3 years after uneventful bilateral laser in situ keratomileusis (LASIK). Slitlamp examination revealed stage 3 DLK with diffuse, multifocal, dot-like, and granular haze in the interface. The DLK did not have an obvious causative agent such as trauma or epithelial defects and responded rapidly to topical corticosteroid therapy. Surgery was performed to relift the flap, remove cellular infiltrates, and obtain cultures. The microbiology culture was negative. This case indicates that DLK can occur several years after LASIK without an obvious cause.