Animal models are the most commonly used model that helps to improve the understanding of the genetic alterations that occur in humans during the carcinogenic environment. Furthermore, these models play a pivotal role in the illustration of tumorigenesis and therapeutic strategies. With the advancement in molecular biology, the use of nanomedicine for breast cancer treatment has progressed, and more is expected to be done in the future pretrial and clinical models to achieve more success. The biocompatibility of 3D printing platforms has been reported to be adequate in terms of cell viability; however the effects on gene expression and functional aspects have received less attention. Various mechanical and visual disruptions to cells are involved depending on the type of bioprinter employed. Additional research into the mechanical and optical effects of the bioprinting process will provide more insight into the 3D printing technique' biocompatibility. To investigate the microenvironment of breast tumours and 3D bioprinting methods have also been studied. Modalities for bioprinting include extrusion-based (EBB) printing, droplet-based (DBB) printing and laser-based bioprinting. Different research has indicated that new developments of novel cancer modelling have emerged with 3D bioprinting technology. Those studies need to be properly explained and analyses in a Broadway in this review and to help in the progress of cancer research.
In the last several years developments in biomaterials and tissue technology have opened the door for novel platform technologies in vitro cancer research, particularly the development of bioprinting techniques. Cells, active compounds and biomaterials can be carefully controlled via bioprinting. In light of this, there are new discoveries of safe and effective forms of treatment to fight the prevalence of the deadly malignant diseases, however most are still under clinical trial model but with promising results. One of the major invasive cancers is breast cancer. This is a heterogeneous kind of cancer that is compounded by the presence and return of tiny groups of stem cells that produce chemical or radiation resistance. Cancer models-modelling an experimental methodology to investigate complex biological systems, has significantly subsidized our understanding of cancer. A two-dimensional cell culture model is particularly difficult to investigate in the cancer environment. More physiologically realistic three-dimensional, in vitro cancer models such as spheroid culture, biopolymer bugs, and cancer on-a-chip equipment have been permitted to develop multiple times in tissue technology. It enables customized tissue models of patients' cancers-specific vascular arrangements and immune cells-to be grown in laboratories for testing. Scientists can then examine the models' responses to chemotherapies and other treatments. Bioprinting cancer technology is free from nature, flexibility, customizability, scalability, and consistency, modeling tumor microenvironments with bio printing has a high potential to reduce difficulties. Those studies need to be properly explained and analyzed in a broad way in this review and to help in the progress of cancer research.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.