Dragon fruit is one of the fruits cultivated in the tropics. The fruit flesh of the dragon fruit has been widely consumed, and the fruit peel of the dragon fruit has also been extensively utilized. But the leaves of the dragon fruit have not been utilized and tend to be waste in agriculture. This study aims to utilize waste dragon fruit leaves with the test of antioxidant activity and the determination of total phenolic of red dragon fruit leaves extract and white dragon fruit leaves extract by spectrophotometric method. Methods performed for antioxidant activity test by 1,1diphenyl-2-picrylhydrazyl (DPPH) with ascorbic acid as the comparator and total phenolic determination by Folin-Ciocalteu (FC) with gallic acid as the comparator. Measurements were done with a spectrophotometer. Antioxidant activity test results of red dragon fruit leaves extract and white dragon fruit leaves extract obtained scavenging concentration 50% (SC50) 135.00 µg/mL and 142.47 µg/mL. Total phenolic determination results of red dragon fruit leaves extract and white dragon fruit leaves extract obtained value 756.75 mg/g and 707.07 mg/g. Both red dragon fruit leaves extract and white dragon fruit leaves extract to have moderate antioxidant activity.
Background: Plectranthus amboinicus (Lour.) Spreng is a plant that has a high flavonoid content. The leaves of Plectranthus amboinicus (Lour.) Spreng contain many flavonoids Chrysoeriol, Cirsimaritin, Eriodictyol, Luteolin, Rutin, Salvigenin, Thymoquinone, Quercetin, Apigenin, and 5-O-Methyl-Luteolin. Objectives: To determine the antioxidant activity and anticancer activity of flavonoid compounds contained in Plectranthus amboinicus (Lour.) Spreng. Methods: Anticancer activity testing was carried out by in silico against several cancer receptors and antioxidant activity testing was carried out by in vitro using the 1,1-Diphenyl-2-Picryhydrazil method. The results showed that the flavonoid compounds contained in Plectranthus amboinicus (Lour.) Spreng have similar anticancer activity to the reference molecule at the P-Glycoprotein-1, Cyclin Dependent Kinase-2, and Phosphoinositide-3-Kinase receptors, as well as better anticancer activity than the reference molecule for the Cyclooxygenase-2 and Phosphoenolpyruvate Carboxykinase receptors. Results: The antioxidant activity of the extract gave an Inhibitory Concentration 50% value of 9.77 µg/mL, the flavonoid compounds contained in Plectranthus amboinicus (Lour.) Spreng gave an Inhibitory Concentration 50% value that lower than the extract, which ranged from 6.92 µg/mL to 8.50 µg/mL. Flavonoids in Plectranthus amboinicus (Lour.) Spreng anticancer activity by in silico molecular docking and antioxidant activity by in vitro 1,1-Diphenyl-2-Picryhydrazil method. Conclusions: All the flavonoid compounds contained in the ethanolic extract of Plectranthus amboinicus (Lour.) Spreng leaves exhibit very strong anti-cancer and antioxidant activity, which results in ethanolic extract of Plectranthus amboinicus (Lour.) Spreng leaves have very strong antioxidant activity.
<p>Besi (Fe) salah satu unsur penting dalam permukaan air dan air tanah. Senyawa besi dalam jumlah kecil di tubuh manusia sebagai pembentuk sel-sel darah merah,tubuh memerlukan 7-35 mg/hari sebagian diperoleh dari air.Tetapi zat Fe yang melebihi dosis dalam tubuh akan menyebabkan masalah kesehatanseperti merusak dinding usus,berkurangnya fungsiparu-paru,dapat menimbulkan noda pada peralatan dan bahan yang berwarna putih.Tujuan penelitian ini untuk mengetahui penurunan kadar besi(Fe) pada air sumur bor dengan metode aerasi-filtrasi pada air sumur bor masyarakat Jalan Setia Budi, Kel.Tanjung Rejo.Jenis penelitian Quasi Eksperimental Design (Rancangan Eksperimen Semu) dengan desain Pre-Test dan Post-Test.Sampel air sumur bor diambil 1 sumur diKelurahan Tanjung Rejo.Pemeriksaan kadar besi(Fe)dilakukan oleh petugas Lab.Lingkungan.Hasil penelitian secara fisik air yang belum diberikan perlakuan memiliki warna kuning, berbau(karat atau tanah),dan air terasa licin ketika sudah diberikan perlakuan dengan lama kontak 30, 45 dan 60 menit dengan metode aerasi-filtrasi air tersebut jernih dan tidak berbau. Sebelum dilakukan aerasi-filtrasi didapat hasil sebesar 4,25mg/l dan proses penurunan kadar besi dengan Metode Aerasi-Filtrasi dengan lama kontak 30 menit sebesar 3,10 mg/l dan 45 menit sebesar 1,85 mg/l belum memenuhi syarat.Pada waktu kontak 60 menit sebesar 1,00 mg/l dan sudah memenuhi syarat baku mutu sesuai Permenkes No.32 Tahun 2017, kadar maksimum besi sebesar 1,00 mg/l.</p>
According to WHO data, there were 6.3 million new pulmonary TB cases, this figure is the same as 61% of the incidence of tuberculosis in the world with a value of 10.4 million. The number of patients with TB increased the number of tuberculosis cases from the previous year, which was 9.6 million people. In addition, the number of deaths caused by tuberculosis worldwide is 40 people per 100,000 of the world's population. The aim of the research was to analyze the adherence of drug users in TB patients to the success of therapy at the Medan Deli Health Center in 2022. The population consisted of 112 pulmonary tuberculosis patients who were treated with a total sampling technique with a total of 112 respondents. The results showed that there was a relationship between adherence and successful therapy for TB patients (p = 0.000), there was a relationship between knowledge and successful therapy for TB patients (p = 0.000), there was no relationship between age and successful therapy for TB patients (p = 0.280), there was no gender relationship with successful therapy for TB patients (p= 0.856), there is a relationship between education and successful therapy for TB patients (p= 0.200), there is a relationship between work and successful therapy for TB patients (p= 0.003), there is a relationship between family support and successful therapy for TB patients (p = 0.010) and multivariate analysis that lack of compliance, lack of knowledge and not working has an effect on the failure of therapy.
This study aimed to examine the mucolytic activity of roselle calyces extract on cow intestinal mucus in vitro. The extraction of rosellecalyces was performed by the subsequence maceration method using different polarity solvent (n-hexane, ethyl acetate, and methanol). Mucolyticactivity of each extract was evaluated by measuring the viscosity of mixture of cow intestinal mucus and phosphate buffer pH 7 compared toacetylcysteine as the standard mucolytic drug. The result showed that the decreasing of cow intestinal mucus and phosphate buffer pH 7 mixturesviscosity was indicated the increasing of mucolytic activity. The n-hexane, ethyl acetate, and methanol extract of roselle calyces exhibit dosedependentmucolytic activity. Mucolytic activity of roselle calyces ethyl acetate extract with dose of 0.8% and roselle calyces methanol extractwith dose of 0.6% showed no significant difference to mucolytic activity from acetylcysteine with dose of 0.1% (positive control). An increaseddose of roselle calyces extract will decrease the viscosity of cow intestinal mucus and phosphate buffer pH 7 mixtures, indicating an increase inmucolytic activity.
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