Most blood plasma zinc is bound to albumin, but the structure of the binding site has not been determined. Zn K-edge extended x-ray absorption fine structure spectroscopy and modeling studies show that the major

Summary. The inflammatory cytokine interferon gamma (IFNg) can cause cell cycle arrest and apoptosis in the hepatocyte. Primarily these processes are protective but in chronic liver disease oncogenic mutations may prosper. IFNg signalling is discussed showing how p53 is induced to cause cell cycle arrest. While caspases are are known to be responsible for IFNg induced apoptosis, how they are activated is unclear. Potential mechanisms are reviewed.