No abstract

Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 infection. 1 A previous study that described MIS-C cases in the first 3 waves of the COVID-19 pandemic found that the proportion of individuals with severe illness declined after the first wave. 2 In Israel, the Omicron (B.1.1.529) variant started to spread in November 2021. 3 We describe outcomes of MIS-C in a multicenter cohort and assessed incidence nationally during the Alpha, Delta, and Omicron variant waves.

We found that infants born with cCMV and hearing impairment, receiving 12 months of antiviral treatment, showed significant improvement in hearing status. The probability of hearing improvement seems inversely related to the severity of the impairment at birth.

EBV infection should be included in the differential diagnosis of CH in all age groups. In the vast majority, full recovery is expected.

Our largest data series highlighted what is known regarding clinical and histological findings in children with AHEI. However, contrary to what was previously reported, we found a higher rate of systemic involvement. Although AHEI is a rare entity, pediatricians should be familiar with its presentation, management and our reported complications.