Reflectance spectra from discrete sites in the human ocular fundus were measured with an experimental reflectometer in the visible and near-infrared parts of the spectrum. The principal study population consisted of ten subjects 22 to 38 years of age with a wide range of degree of fundus melanin pigmentation. Reflectance spectra were obtained from the nasal fundus, the fovea, and an area 2.5 degrees from the fovea. Spectra were also recorded from several older subjects and from one aphakic patient with a coloboma. The reflectance spectra were found to be influenced by the degree of individual and local melanin pigmentation of the fundus, the amount of blood in the choroid, the transmission properties of the ocular media, and the discrete reflections in the stratified fundus layers. Mathematical models of the optical properties of the stratified layers are proposed and are fitted to the experimental fundus reflectance spectra. The models account for the absorption by blood, melanin, macular pigment, and ocular media, and incorporate tissue scattering and discrete reflectors corresponding to anatomical layers.
A computer model of relative retinal illuminance, based on our optical wide-angle model of the eye, is proposed for the cases of Ganzfeld illumination and the Maxwellian view through a range of visual field angles from 0 degrees to 80 degrees. The proposed model is designed to be functionally correct and to represent closely the anatomical parameters of the eye. Unlike earlier proposed models, this model is based on our previously reported measurements of spherical aberration in 100 eyes in vivo and is designed to be correct in the peripheral field and with large pupils. Data are reported for pupil diameters of 2, 4, and 8 mm. The effect of crystalline lens extinction on retinal illumination is also estimated for average eyes of young (age 19 years) and old (age 63 years) individuals at two wavelengths (410 and 532 nm). In the Ganzfeld case, illumination of the retina decreases with increasing visual angle. In the Maxwellian view, retinal illuminance increases with increasing visual angle.
A dosimetry technique has been developed which utilizes three-wavelength fundus reflectometry, a quantitative model of fundus reflectance, and a model of thermal tissue damage to control photocoagulation lesion size. The fundus reflectance model uses Lambert-Beer's law exponential attenuators to describe the ocular media, retinal pigment epithelium (RPE), and choriocapillaris transmission characteristics while the choroid is described as a Kubelka-Munklike homogeneous scatterer/absorber. Three reflecting layers are included in the model at the retinal inner limiting membrane, Bruch's membrane, and the sclera. Measured lesion size variability contained components which resulted from variations in choroidal blood and melanin and RPE melanin concentration. Photocoagulation dosimetry was found to reduce the photocoagulation lesion size coefficient of variation for red light from 45% to 10% for the control and dosimetry cases, respectively. Similar improvement was noted for yellow photocoagulation light.
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