Chromosomal alterations were investigated in hepatocellular carcinoma cell lines, primary tumors and liver epithelial cell lines derived from normal livers of C57BL/6JxC3H/HeJ F(1) and C3H/HeJxC57BL/6J F(1) mice. In the primary tumors, non-random gain of chromosomes 15 and 19 was found in seven and five of 14 hepatocellular carcinomas, respectively. On the other hand, in the cases of both liver epithelial and hepatocellular carcinoma cell lines, frequent changes were loss of chromosomes 4 (4/9 cell lines) and 12 (3/9) as well as gain of chromosomes 15 (5/9) and 19 (4/9). These results indicate that the chromosomal gain is associated with both in vivo carcinogenesis and establishment of cell lines, while the loss is specific for the latter. PCR analysis using polymorphic microsatellite DNA markers revealed that the loss of chromosome 12 as well as chromosome 4 was much more frequent for the C57BL/6J hepatocarcinogenesis-resistant rather than the susceptible C3H/HeJ strain.
A 61-year-old male presented with a hypervascular variant of dysplastic gangliocytoma (Lhermitte Duclos disease) manifesting as gait disorder. Computed tomography and magnetic resonance imaging both showed enhancement of the tumor after injection of contrast medium. Angiography demonstrated a tumor stain. Histological examination showed a double-layered structure comprising an outer layer of myelinated axons and an inner layer of dysplastic granular cells, and numerous dilated thin-walled blood vessels. Partial resection of the tumor resulted in resolution of the neurological deficit.
A 63-year-old woman demonstrated subclavian steal syndrome. She had been diagnosed with radio-cephalic AVF(RCAVF)13 years earlier. MRA and cerebral angiogram demonstrated retro-grade filling of the left vertebral artery. SPECT demonstrated lowered blood supply of the left cereberal area that disappeared following administration of Diamox. Doppler examination demonstrated retrograde flow of the left vertebral artery. With simple manual compression of the AVF anastomosis of the left wrist, Doppler wave form changed from a retrograde to a normal antegrade form. Estimation of the left brachial arterial flow by Doppler examination was 3.5 / L/min. We concluded that SSS of this case caused by lowered subclavian arterial pressure and high blood flow speed derived from high flow RCAVF. Vertibrobasilar insufficiency symptoms disappeared after closure of RCAVF.
ABSTRACT:The structural change of the end groups of UVcured acrylates with time has been investigated as well as photopolymerization behavior. 2-Ethylhexyl acrylate, n-lauryl acrylate, 2-(2-ethoxyethoxy)ethyl acrylate, and 2-ethylhexyl methacrylate were used as a monomer in the current study. In order to mimic industrial conditions, the photopolymerization was conducted with relatively high UV intensity (576 mW/cm 2 ) using a common photoinitiator 1-hydroxycyclohexyl phenyl ketone. Conversion-time profile gave a linear first-order plot suggesting that the steady state was hold throughout the polymerization. Matrix-assisted laser desorption/ionization time-offlight mass spectra of the resultant polymers indicated the number of the hydroxycyclohexyl chain-ends decreased with storage time at room temperature. Instead, a lactonic ring appeared to form at the chain-end by transesterification of the hydroxycyclohexyl group with the ester side chain of the adjacent acrylate according to the results of mass spectrometry and 13 C NMR.
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