The aim of this study is to investigate, by a validated in vitro model, the effect of diabetic plasma on ejaculated human spermatozoa. Plasma of 51 male diabetic patients (mean age 62.28 ± 9.28 years) was selected according to their HbA 1c level: low HBA 1c ≤ 5% (31 mmol/mol), moderate HBA 1c 6%-8% (42-64 mmol/mol) and high HBA 1c ≥ 10% (86 mmol/mol). The plasma was tested on eighteen normal semen samples by analysing gametes motility using a computer Sperm Class Analyzer® and their corresponding oxidative stress (OS) status using thiobarbituric acid-reactive substances assay. The results indicated that diabetic plasma affected all sperm motil-How to cite this article: Chemlal H, Bensalem S, Bendiab K, et al. High HbA 1c levels affect motility parameters and overexpress oxidative stress of human mature spermatozoa.
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