The neurotransmitter oxytocin plays an important role in social affiliation. Low oxytocin levels and defects in the oxytocin receptor have been reported in childhood autism. However, little is known about oxytocin’s post-receptor signaling pathways in autism. Oxytocin signals via stimulatory and inhibitory G proteins. c-fos mRNA expression has been used as a marker of OT signaling as well as of G protein signaling. Herein, we hypothesized that oxytocin and its signaling pathways would be altered in children with autism. We measured plasma oxytocin levels by ELISA, G-protein and c-fos mRNA by PCR, and G proteins by immunoblot in cultured peripheral blood mononuclear cells (PBMCs) in children with autism and in age-matched controls. Males with autism displayed elevated oxytocin levels compared to controls (p<0.05). Children with autism displayed significantly higher mRNA for stimulatory G proteins compared to controls (p<0.05). Oxytocin levels correlated strongly positively with c-fos mRNA levels, but only in control participants (p<0.01). Oxytocin, G-protein, and c-fos mRNA levels correlated inversely with measures of social and emotional behaviors, but only in control participants. These data suggest that children with autism may exhibit a dysregulation in oxytocin and/or its signaling pathways.

Background and Objectives: Virtual residency interviews during the 2020 COVID-19 pandemic posed unique challenges to students and residency programs in the United States. We evaluated fourth-year medical students’ perceptions of the virtual format and social media use to help select residency programs. We also assessed applicant utilization and perceived usefulness of our social media content. Methods: We administered an anonymous, web-based survey study of interviewees at an urban, academic medical center residency program. We analyzed data using descriptive statistics. Results: Seventy-five of 138 applicants completed the survey (response rate 54%). Most applicants reported worry about obtaining enough information about residency programs to apply (64%) and to rank programs (87%). Though more traditional information sources remain most prevalent, social media is now widely used to research residency programs (62%). Conclusions: Most applicants to this family medicine residency program used social media to gather information, but they expressed worry that it was enough. Virtual interviews are likely to remain postpandemic, creating challenges for residency programs and especially for their hopeful applicants. Programs seeking to provide well-rounded information for applicants should maintain a social media presence as part of their recruitment practices.

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