A three component palladium catalysed cascade reaction was employed in the regiospecific and stereoselective synthesis of novel substituted (Z) 2-butene 1,4 diamine analogues and substituted 4-aryloxy but-2-enyl amine analogues. Allenes were first synthesised from the corresponding alkynes using a Crabbé reaction and then reacted with a large range of commercially available aryl iodides and amines to generate a library of small molecules. The reaction is compatible with aryl iodides containing both electron donating and electron withdrawing groups. Amines of different sizes can also be utilised with no noticeable effect on the yield, regiospecificity or stereoselectivity.
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