Background:The highly regulated hypoxia-inducible factor 1␣ (HIF-1␣) is a key player in the cellular response to hypoxia. Results: The ubiquitin-specific protease 19 (USP19) rescues HIF-1␣ from degradation in a non-catalytic manner. Conclusion: USP19 is required for cells to mount an appropriate response to hypoxia. Significance: Learning about HIF-1␣ regulation is essential for understanding the physiological and pathophysiological conditions of the hypoxic response.
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