Neuronal systems have been modelled by complex networks in different description levels. Recently, it has been verified that networks can simultaneously exhibit one coherent and other incoherent domain, known as chimera states. In this work, we study the existence of chimera-like states in a network considering the connectivity matrix based on the cat cerebral cortex. The cerebral cortex of the cat can be separated in 65 cortical areas organised into the four cognitive regions: visual, auditory, somatosensory-motor and frontolimbic. We consider a network where the local dynamics is given by the Hindmarsh-Rose model. The Hindmarsh-Rose equations are a well known model of neuronal activity that has been considered to simulate membrane potential in neuron. Here, we analyse under which conditions chimera-like states are present, as well as the affects induced by intensity of coupling on them. We identify two different kinds of chimera-like states: spiking chimera-like with desynchronised spikes, and bursting chimera-like with desynchronised bursts. Moreover, we find that chimera-like states with desynchronised bursts are more robust to neuronal noise than with desynchronised spikes.
We have studied neuronal synchronisation in a random network of adaptive exponential integrate-and-fire neurons. We study how spiking or bursting synchronous behaviour appears as a function of the coupling strength and the probability of connections, by constructing parameter spaces that identify these synchronous behaviours from measurements of the inter-spike interval and the calculation of the order parameter. Moreover, we verify the robustness of synchronisation by applying an external perturbation to each neuron. The simulations show that bursting synchronisation is more robust than spike synchronisation.
Functional brain networks are composed of cortical areas that are anatomically and functionally connected. One of the cortical networks for which more information is available in the literature is the cat cerebral cortex. Statistical analyses of the latter suggest that its structure can be described as a clustered network, in which each cluster is a scale-free network possessing highly connected hubs. Those hubs are, on their hand, connected together in a strong fashion ("rich-club" network). We have built a clustered scale-free network inspired in the cat cortex structure so as to study their dynamical properties. In this article, we focus on the synchronization of bursting activity of the cortical areas and how it can be suppressed by means of neuron deactivation through suitably applied light pulses. We show that it is possible to effectively suppress bursting synchronization by acting on a single, yet suitably chosen neuron, as long as it is highly connected, thanks to the "rich-club" structure of the network.
Chemotherapy is a cancer treatment modality that uses drugs to kill tumor cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks. We present mathematical analyses demonstrating the existence of a maximum time between cycles of chemotherapy for a protocol to be effective. A mathematical equation is derived, which relates such a maximum time with the variables that govern the kinetics of the tumor and those characterizing the chemotherapeutic treatment. Our results suggest that there are compelling arguments supporting the use of dose-dense protocols. Finally, we discuss the limitations of these protocols and suggest an alternative.
In this work we investigate a mathematical model describing tumour growth under a treatment by chemotherapy that incorporates time-delay related to the conversion from resting to hunting cells. We study the model using values for the parameters according to experimental results and vary some parameters relevant to the treatment of cancer. We find that our model exhibits a dynamical behaviour associated with the suppression of cancer cells, when either continuous or pulsed chemotherapy is applied according to clinical protocols, for a large range of relevant parameters. When the chemotherapy is successful, the predation coefficient of the chemotherapic agent acting on cancer cells varies with the infusion rate of chemotherapy according to an inverse relation. Finally, our model was able to reproduce the experimental results obtained by Michor and collaborators [Nature, 435, 1267[Nature, 435, (2005] about the exponential decline of cancer cells when patients are treated with the drug glivec.
In this paper, we study the effects of spike timing-dependent plasticity on synchronisation in a network of Hodgkin-Huxley neurons. Neuron plasticity is a flexible property of a neuron and its network to change temporarily or permanently their biochemical, physiological, and morphological characteristics, in order to adapt to the environment. Regarding the plasticity, we consider Hebbian rules, specifically for spike timing-dependent plasticity (STDP), and with regard to network, we consider that the connections are randomly distributed. We analyse the synchronisation and desynchronisation according to an input level and probability of connections. Moreover, we verify that the transition for synchronisation depends on the neuronal network architecture, and the external perturbation level.
Excessively high, neural synchronization has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding of neural synchronization mechanisms can thus help control or even treat epilepsy. In this paper, we study neural synchronization in a random network where nodes are neurons with excitatory and inhibitory synapses, and neural activity for each node is provided by the adaptive exponential integrate-and-fire model. In this framework, we verify that the decrease in the influence of inhibition can generate synchronization originating from a pattern of desynchronized spikes. The transition from desynchronous spikes to synchronous bursts of activity, induced by varying the synaptic coupling, emerges in a hysteresis loop due to bistability where abnormal (excessively high synchronous) regimes exist. We verify that, for parameters in the bistability regime, a square current pulse can trigger excessively high (abnormal) synchronization, a process that can reproduce features of epileptic seizures. Then, we show that it is possible to suppress such abnormal synchronization by applying a small-amplitude external current on > 10% of the neurons in the network. Our results demonstrate that external electrical stimulation not only can trigger synchronous behavior, but more importantly, it can be used as a means to reduce abnormal synchronization and thus, control or treat effectively epileptic seizures.
In recent years, it became clear that a better understanding of the interactions among the main elements involved in the cancer network is necessary for the treatment of cancer and the suppression of cancer growth. In this work we propose a system of coupled differential equations that model brain tumour under treatment by chemotherapy, which considers interactions among the glial cells, the glioma, the neurons, and the chemotherapeutic agents. We study the conditions for the glioma growth to be eliminated, and identify values of the parameters for which the inhibition of the glioma growth is obtained with a minimal loss of healthy cells.
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