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An optical wireless communication (OWC) system based on a light-emitting-diode (LED) transmitter and a camera receiver has been developed for use in the automotive area. The automotive OWC system will require Mb/s-class data rates and the ability to quickly detect LEDs from an image. The key to achieving this is improvements to the capabilities of the image sensor mounted on the camera receiver. In this paper, we report on a novel OWC system equipped with an optical communication image sensor (OCI), which is newly developed using CMOS technology. To obtain higher transmission rates, the OCI employs a specialized Bcommunication pixel (CPx)[ capable of responding promptly to optical intensity variations. Furthermore, a new quick LED detection technique, based on a 1-bit flag image which only reacts to high-intensity objects, is formulated. The communication pixels, ordinary image pixels, and associated circuits (including 1-bit flag image output circuits) are then integrated into the OCI. This paper describes the design, fabrication, and capabilities of the OCI, as well as the development of the LED and image sensor based OWC system, which boasts a 20-Mb/s/pixel data rate without LED detection and a 15-Mb/s/pixel data rate with a 16.6-ms real-time LED detection. Index Terms: Optical wireless communication (OWC), visible light communication (VLC), light-emitting diode (LED), complementary metal-oxide-semiconductor (CMOS) image sensor, image sensor based OWC, automotive communication system.

This paper introduces an optical vehicle-to-vehicle (V2V) communication system based on an optical wireless communication technology using an LED transmitter and a camera receiver, which employs a special CMOS image sensor, i.e., an optical communication image sensor (OCI). The OCI has a "communication pixel (CPx)" that can promptly respond to light intensity variations and an output circuit of a "flag image" in which only high-intensity light sources, such as LEDs, have emerged. The OCI that employs these two technologies provides capabilities for a 10-Mb/s optical signal reception and real-time LED detection to the camera receiver. The optical V2V communication system consisting of the LED transmitters mounted on a leading vehicle and the camera receiver mounted on a following vehicle is constructed, and various experiments are conducted under real driving and outdoor lighting conditions. Due to the LED detection method using the flag image, the camera receiver correctly detects LEDs, in real time, in challenging outdoor conditions. Furthermore, between two vehicles, various vehicle internal data (such as speed) and image data (320 Â 240, color) are transmitted successfully, and the 13.0-fps image data reception is achieved while driving outside.

BackgroundStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions associated with fatal disorders. Although many causes of SJS/TEN have been proposed, the time-to-onset for SJS/TEN and the relationship between aging and SJS/TEN are still not clear. Therefore, the aim of this study was to determine the relationship between aging and SJS/TEN using the Japanese Adverse Drug Event Report (JADER) database and analyze the time-to-onset profile of SJS/TEN.MethodsWe analyzed reports of SJS/TEN recorded in the JADER database between 2004 and 2015 using an adjusted reporting odds ratio (ROR). We also used Weibull proportional hazards models for each drug to examine the expression patterns of SJS/TEN. We selected the drugs according to the number of the reports associated with SJS/TEN.ResultsThe JADER contained 330,686 reports from April 2004 to April 2015. The adjusted RORs for patients in the 0–19-, 20–39-, 60–79-, and ≥ 80-year-old groups from all data extracted from the JADER database were 1.33 (95 % confidence interval [CI], 1.21–1.45), 1.78 (95 % CI, 1.65–1.93), 0.71 (95 % CI, 0.66–0.75), and 0.72 (95 % CI, 0.66–0.79), respectively. The adjusted ROR tended to be higher in patients aged 0–19 years, particularly in patients using antipyretic analgesics, such as loxoprofen or acetaminophen. More than half of the cases of SJS/TEN onset following administration of loxoprofen and acetaminophen occurred within 4 days of the initiation of treatment. The median times-to-onset were 3 days for loxoprofen and 2 days for acetaminophen. The scale parameter α values of loxoprofen and acetaminophen were 9.44 and 6.17, respectively. The upper 95 % CIs of shape parameter β values for the drugs were all less than 1, with the exceptions of those for carbamazepine, ACE inhibitors, and corticosteroids.ConclusionsOur results suggested that monitoring of younger patients who frequently use antipyretic analgesics is important. These drugs should be used and monitored within the first 2–3 days of treatment in the Japanese population.

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