These results suggest that acute stress modifies the allergic airway responses distinctively depending on the genetic background, and MOR is involved in the chronic psychological stress-induced exacerbation of allergic airway inflammation.
AT1a might be involved in the negative regulation of the development of allergic airway inflammation through polarizing the T-helper (Th) balance towards Th1 predominance. Therefore, it would be of clinical importance to investigate the effects of long-term administration of AT1 blockers on the Th1/Th2 balance in hypertensive patients with bronchial asthma.
AimsTo investigate the correlation between in vitro permeation of 11 β -lactam antibiotics across rat jejunum and their oral bioavailability in humans. Methods The absorptive and secretory permeation across rat jejunum was evaluated and apparent permeability coefficients (P app ) were determined. Results A steep, sigmoid-type curve was obtained for the relationship between P app in the absorptive permeation and human oral bioavailability. When the ratios of P app in the absorptive direction to P app in the secretory direction were plotted against human oral bioavailability, a much improved correlation was obtained ( r = 0.98, P < 0.001). The addition of glycylglycine to both mucosal and serosal media modified the permeation of ceftibuten and cephalexin from the absorptive to the secretory direction. Conclusions For 11 β -lactam antibiotics rat intestinal permeation correlated well with human oral bioavailability, especially when corrected for secretory transport.
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