Bullous pemphigoid (BP) has never before been reported to associate with silicosis, although there are numerous reports of silicosis accompanied by different autoimmune diseases, such as systemic sclerosis, systemic lupus erythematosus, dermatomyositis or rheumatoid arthritis. We report on a 63-year-old Japanese patient with silicosis who developed tensed bullae, erosions and macular pigmentation on the trunk and extremities. Indirect immunofluorescence revealed anti-basement-membrane-zone antibodies; immunoblotting analysis demonstrated that the patient’s serum reacted with the 230-kD BP antigen in the epidermal extracts, as well as a recombinant protein of the NC16a domain of 180-kD BP antigen. Clinical symptoms improved after treatment with systemic steroids. To the best of our knowledge, this is the first reported case of BP associated with silicosis.
Acase of tuberculous lymphadenitis is reported . The patient was a 40 − year − old woman . She visited our hospital with a chief complaint of a painless swelli at the left submandibular gland . In clinical diagnosis , tumor of submandibular gland was suspected and it was removed under general anesthesia . Postoperativelly tuberculous focus was not recognized in other organs at physica 監 examlnatlon Kyushu Dental Sooiety
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