6-N-or N'-Alkylation of 6-N-acyl adenosine derivatives with alkyl halides in CH,CI,-l mol dm-3 NaOH in the presence of Bu,NBr has been studied. A variety of N-acyl groups have been examined. Consequently, the use of the acetyl and 2-(trimethylsilyl)ethoxycarbonyl groups resulted in the corresponding 6-N-alkylated products in high yields. It was also found that, when the benzoyl group was chosen as the N-acyl group, N l-alkylated products were obtained along with 6-N-alkylated products. The structure of the 6-N-and N -alkylated adenosine derivatives has been determined by 'H and 13C NMR spectroscopy.Paper 5/00999E
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