Several lines of evidence indicate that estrogen affects hippocampal synaptic plasticity through rapid nongenomic mechanisms, possibly by binding to plasma membrane estrogen receptors (ERs). We have previously shown that ERalpha immunoreactivity (ir) is in select interneuron nuclei and in several extranuclear locations, including dendritic spines and axon terminals, within the rat hippocampal formation (Milner et al., [2001] J Comp Neurol 429:355). The present study sought to determine the cellular and subcellular locations of ERbeta-ir. Coronal hippocampal sections from diestrus rats were immunolabeled with antibodies to ERbeta and examined by light and electron microscopy. By light microscopy, ERbeta-ir was primarily in the perikarya and proximal dendrites of pyramidal and granule cells. ERbeta-ir was also in a few nonprincipal cells and scattered nuclei in the ventral subiculum and CA3 region. Ultrastructural analysis revealed ERbeta-ir at several extranuclear sites in all hippocampal subregions. ERbeta-ir was affiliated with cytoplasmic organelles, especially endomembranes and mitochondria, and with plasma membranes primarily of principal cell perikarya and proximal dendrites. ERbeta-ir was in dendritic spines, many arising from pyramidal and granule cell dendrites. In both dendritic shafts and spines, ERbeta-ir was near the perisynaptic zone adjacent to synapses formed by unlabeled terminals. ERbeta-ir was in preterminal axons and axon terminals, associated with clusters of small, synaptic vesicles. ERbeta-labeled terminals formed both asymmetric and symmetric synapses with dendrites. ERbeta-ir also was detected in glial profiles. The cellular and subcellular localization of ERbeta-ir was generally similar to that of ERalpha, except that ERbeta was more extensively found at extranuclear sites. These results suggest that ERbeta may serve primarily as a nongenomic transducer of estrogen actions in the hippocampal formation.
This article centres on the social activity of haggling during service encounters in a typical Nigerian urban market place. The data corpus is derived from transactions between meat vendors and customers at meat stalls in some markets in Lagos, Nigeria. Haggling exchanges between meat vendors and their customers were secretly recorded and subsequently analysed to elicit the significant elements of haggling; identify the stages in a haggling exchange; and describe the discourse strategies employed by both classifications of interactant (vendor and buyer) involved in the socio-linguistic activity. The findings revealed that English, Pidgin and Yoruba were generally used in the transactions. The findings also revealed that both categories of interactant employed discourse strategies which include humour, dysphemism and euphemism, cajoling, flattery and flirting to achieve their ultimate goal of maximizing profit/bargain during the buying and selling encounters.
This paper examines the media representation of the socio-political discourse that centres on the activities of Boko Haram, a Nigeria-based militant Islamic group that has been responsible for violent attacks on individuals and institutions in the country. The data for the study was derived from newspaper reports published in July and August 2011 in the wake of the bombing of the nation's police headquarters and the United Nation's House in Abuja, Nigeria. The theoretical framework employed for the analysis is Critical Discourse Analysis. This interdisciplinary and inter-discursive approach made the application of historical and ideological analysis possible. The authors were able to elicit the media representation of Boko Haram as a militant Islamic group with allies and members outside Nigeria. The group is also represented as one that has an international socio-political agenda that could threaten regional peace and the continued existence of Nigeria as a peaceful and stable polity. The paper concludes that contrary to scepticisms about daily newspapers as purveyors of misery and libel, Nigerian national newspapers serve as a source of accurate information and perceptive analysis on Boko Haram, a socio-political group whose actions are inimical to public peace and Nigeria's political stability. The paper concludes that the bombing of the Nigeria Police Headquarters and the United Nations House in Abuja by the group exposed the ill-preparedness of Nigerian security agencies to meet the security challenges of the 21st century.
This paper examines a trend in Nigeria whereby children of Yoruba-speaking parents acquire English as their First Language and Yoruba as their second language. It assesses the socio-cultural implications of this practice on the country's socio-political development. Forty school children and their parents were purposively selected and administered questionnaires aimed at eliciting their language preferences in different domains. The results showed that English was the preferred language used by the children in eight out of the twelve domains of language use. The paper concluded by recommending that indigenous languages be used for legislation, administration, and education in Nigeria.
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