BackgroundThe emergence and spread of insecticide resistance in the major African malaria vectors Anopheles gambiae (s.s.) and An. arabiensis may compromise the current vector control interventions and threatens the global malaria control and elimination efforts.MethodsInsecticide resistance was monitored in several study sites in Ethiopia from 2013 to 2015 using papers impregnated with discriminating concentrations of DDT, deltamethrin, bendiocarb, propoxur, malathion, fenitrothion and pirimiphos-methyl, following the WHO insecticide susceptibility test procedure. Mosquitoes sampled from different localities for WHO bioassay were morphologically identified as An. gambiae (s.l.) using standard taxonomic keys. Samples were identified to species using species-specific polymerase chain reaction (PCR) and screened for the presence of target site mutations L1014F, L1014S and N1575Y in the voltage gated sodium channel (VGSC) gene and G119S in the acethylcholinesterase (AChE) gene using allele-specific PCR. Biochemical assays were performed to assess elevated levels of acetylcholinesterases, carboxylcholinesterases, glutathione-S-transferases (GSTs) and cytochrome P450s monooxygenases in wild populations of An. arabiensis, compared to the fully susceptible Sekoru An. arabiensis laboratory strain.ResultsPopulations of An. arabiensis were resistant to DDT and deltamethrin but were susceptible to fenitrothion in all the study sites. Reduced susceptibility to malathion, pirimiphos-methyl, propoxur and bendiocarb was observed in some of the study sites. Knockdown resistance (kdr L1014F) was detected in all mosquito populations with allele frequency ranging from 42 to 91%. Elevated levels of glutathione-S-transferases (GSTs) were detected in some of the mosquito populations. However, no elevated levels of monooxygenases and esterases were detected in any of the populations assessed.Conclusions Anopheles arabiensis populations from all surveyed sites in Ethiopia exhibited resistance against DDT and pyrethroids. Moreover, some mosquito populations exhibited resistance to propoxur and possible resistance to bendiocarb. Target site mutation kdr L1014F was detected in all mosquito populations while elevated levels of glutathione-S-transferases (GSTs) was detected in some mosquito populations. The reduced susceptibility of An. arabiensis to propoxur and bendiocarb, which are currently used for indoor residual spraying (IRS) in Ethiopia, calls for continuous resistance monitoring, in order to plan and implement evidence based insecticide resistance management.Electronic supplementary materialThe online version of this article (10.1186/s13071-017-2342-y) contains supplementary material, which is available to authorized users.

BackgroundChloroquine is an anti-malarial drug being used to treat Plasmodium vivax malaria cases in Ethiopia. However, emergence of chloroquine resistant strains of the parasite has challenged the current efficacy of the drug. Therefore, the aim of this study was to assess the effectiveness of chloroquine against P. vivax strains in one of the malaria endemic areas of Ethiopia, namely Halaba district, located in South Nations and Nationalities Peoples Region (SNNPR) of South EthiopiaResultsAmong 87 malaria patients enrolled in the study, only 80 of them completed the 28-days follow-up. Seven of them dropped from the study for different reasons. Among those study participants that completed their follow-up, 69 were classified under the category of adequate clinical and parasitological response (ACPR). However, the remaining 11 cases were considered as under treatment failure mainly due to recurrence of parasitemia on day 7 (four patients), day 14 (six patients), and day 21 (one patient). The age of all cases of treatment failures was found to be less than 20 years. The load of parasitemia of patients with treatment failure on day of admission (4709.4/μl) was higher than day of recurrence (372.37/μl). Parasite reduction ratio (PRR) of treatment failure cases was 12.6/μl.ConclusionThis report revealed the rise in treatment failure (13% [95% CI = 0.074 - 0.217]) as compared to earlier reports from Ethiopia. It signals the spreading of chloroquine resistant P. vivax (CRPv) strains to malaria endemic areas of Ethiopia. It is recommended that all concerned bodies should act aggressively before further expansion of the current drug resistant malaria.

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The Gilgel Gibe catchment in SW Ethiopia is one of the areas in East Africa affected by landslides. To better understand the patterns and the causal factors of these landslides, all landslides in a small study area (14 km²) in the hilly parts of the Gilgel Gibe catchment were mapped and analyzed. In total, 60 landslides were mapped. These landslides caused a displacement of 1 million m³ slope material, which corresponds to a mean displaced volume of 50 ton ha-1 y-1 in the last 20 years. Moreover many landslides deliver directly sediment to the rivers and hence increase the sediment load in the rivers. This soil loss to the rivers was estimated at 11 ton ha-1 y-1 during the same period. High annual rainfall (ca. 2000 mm y-1), lithological and pedological properties and to a lesser extent steep (> 16°) slopes turn the area into an inherent unstable situation and can be indicated as preconditions for the landslides in the study area. Distance to rivers is significantly the most important precondition, as slopes near rivers are less stable than slopes This article is published as: N. Broothaerts, E. Kissi, J. Poesen, A. Van Rompaey, K. Getahun, E. Van Ranst, J. Diels (2012) Spatial patterns, causes and consequences of landslides in the Gilgel Gibe catchment, SW Ethiopia. Catena, 97, 127-136. 2 further away from the rivers. This is mainly caused by river incision and bank erosion which often occur in the area and which can be attributed to increased runoff due to deforestation over the past 20 years. Therefore recent deforestation caused more shallow landslides but also indirectly more deep-seated landslides close to the rivers. Heavy rainfall is indicated as the main triggering factor for almost all landslides.