Resveratrol (trans-3,4N,-5-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound with potential anticancer properties. Here we show that resveratrol affects the growth of human breast cancer cell lines MCF7, MDA-MB-231, SK-BR-3, and Bcap-37 in a dose-dependent manner and that MCF7 is the most sensitive among the four cell lines. MCF7 cells treated with resveratrol showed typical characteristics of apoptosis including the poly (ADP-ribose) polymerase cleavage, TdT-mediated dUTP nick end labeling-positive staining, and morphologic changes. Phosphorylation of the oncogene product Akt was significantly reduced followed by decreased phosphorylation and increased processing of pro-caspase-9 on resveratrol treatment. These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway.
According to the SRAM-based FPGA's single event effect problem in space application, single event upset induced multiblock error (SEU-MBE) phenomenon and its mitigation strategy are studied in the paper. After analyzing the place and route result, the paper points out that the essence of SEU-MBE is that some important modules exceed the safe internal distance. Two approaches, area constraint method (ACM) and incremental route algorithm (IRA), are proposed, which can reduce the error rate by manipulating programmable switch matrix and interconnection points within FPGA route resource. Fault injection experiments indicate that error detection rate is above 98.6% for both strategies, and FPGA resources increment and performance penalty are around 10%.
SRAM-based FPGA, single event upset induced multi-block error, place and route
Citation:Xing K F, Yang J W, Zhang C S, et al. Single event upset induced multi-block error and its mitigation strategy for SRAM-based FPGA.
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