Introduction: The use of growth factors and cytokines in skin rejuvenation and reversal of photo ageing is a novel anti-ageing treatment. These factors provide a microenvironment that seems to favor tissue repair and regeneration. Methods: An open label, monocentric, single arm study to evaluate anti-ageing efficacy of conditioned medium obtained from adult human bonemarrow derived allogenic mesenchymal stromal cells (BMMSC) along with excipients formulated into a cosmetic serum, was conducted in 40 Indian female population aged 35 to 60 years, belonging to skin type IV -VI of Norwood Scale for a duration of 90 days. Parameters-fine lines, wrinkles, crow's feet, evenness of skin tone, skin firmness/laxity, hydration of skin, homogeneity of age spots, and visible pores were used to evaluate the anti-ageing and rejuvenating properties of the test product. Results and Discussion: Improvement was seen in majority of parameters starting from 15 -30 days. Product was safe and well tolerated as per the dermatologist and subjects' self-assessment.
We report two cases of abrupt onset centro-facial pigmentation associated with acute viral fever and arthralgia. Review of literature yielded reports of similar pigmentation along with other dermatological manifestations like maculopapular rash, vesiculobullous lesions etc. In our cases centrofacial pigmentation confined to nose was the only presenting symptom and required treatment from patient's perspective.Centro-facial melanosis may be considered as a sign of acute viral fever which could require specific treatment.The aim of our report is to widen the vision of clinicians in considering abrupt onset of centro-facial melanosis as a presenting symptom in an acute sero-negative viral fever with arthralgia.
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