Although ganglion cell inner plexiform layer (GC-IPL) analysis in the patients with high myopia is useful, there have been few reports to analyze of the reliability for long-term measured GC-IPL thickness. We aimed to analyze the long-term reproducibility of thickness measurements of the GC-IPL using spectral-domain optical coherence tomography (SD-OCT) in patients with high myopia and identify factors that affect such reproducibility. 99 eyes from 99 patients with high myopia without any other ophthalmc disorder such as glaucoma or retinal diseases were included. Two serial SD-OCT (Cirrus-HD) macular scans taken at ≧1 year intervals were analyzed. The intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest standard deviation (TRTSD) of GC-IPL thickness measurements were assessed. The ICC, CV, and TRTSD of the mean GC-IPL thicknesses were 0.883, 5.9%, and 2.74, respectively. The ICCs of the six-sector GC-IPL thicknesses ranged from 0.740 to 0.904. The CVs of the minimal and all sectoral GC-IPL thicknesses were <10%. Measurement variances for the mean GC-IPL thicknesses showed significant relationshiups with chorioretinal atrophy and posterior staphyloma. There is high long-term reproducibility in GC-IPL thickness measurements using SD-OCT in high-myopia patients. The factors affecting this reproducibility include chorioretinal atrophy and posterior staphyloma.

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The purpose of this study was to identify differences in retinal microvasculature impairments between patients with normal-tension glaucoma (NTG) and those with primary open-angle glaucoma (POAG) with similar extents of structural and visual field damage. Participants with glaucoma-suspect (GS), NTG, POAG, and normal controls were consecutively enrolled. Peripapillary vessel density (VD) and perfusion density (PD) were compared among the groups. Linear regression analyses were performed to identify the relationship between VD, PD and visual field parameters. The VDs of the full areas were 18.3 ± 0.7, 17.3 ± 1.7, 16.5 ± 1.7, and 15.8 ± 2.3 mm−1 in the control, GS, NTG, and POAG groups, respectively (P < 0.001). The VDs of the outer and inner areas and the PDs of all areas also differed significantly among the groups (all P < 0.001). In the NTG group, the VDs of the full, outer, and inner areas were significantly associated with all visual field parameters including the mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). In the POAG group, the VDs of the full and inner areas were significantly associated with PSD and VFI but not with MD. In conclusion, with similar degrees of retinal nerve fiber layer thinning and visual field damage in both groups, the POAG group showed a lower peripapillary VD and PD than the NTG group. VD and PD were significantly associated with visual field loss.