A519reimbursable drugs, has abolished the requirement, highlighting the potential practical difficulties in obtaining such prices. One country (Switzerland) has recently proposed amendments to its IRP methodology to focus on discounted rather than listed prices. ConClusions: IRP is increasing as a core market access risk globally, with the knock-on implications of low prices or price cuts in one country into other countries becoming a more tangible and complex threat. IRP is increasing both in terms of geographic scope and also in terms of the precise method of use. The shift from using manufacturing prices towards discounted prices, and the increasing transparency over net prices, represent a significant ongoing threat, and the practical implications are wide-ranging. It has the counter-productive effective of rendering pharmaceutical companies less willing and likely to engage in discounts.
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