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Obsessive-compulsive disorder (OCD) is a common and often debilitating neuropsychiatric condition characterized by persistent intrusive thoughts (obsessions), repetitive ritualistic behaviours (compulsions) and excessive anxiety. While the neurobiology and etiology of OCD has not been fully elucidated, there is growing evidence that disrupted neurotransmission of glutamate within corticalstriatal-thalamocortical (CSTC) circuitry plays a role in OCD pathogenesis. This review summarizes the findings from neuroimaging, animal model, candidate gene and treatment studies in the context of glutamate signalling dysfunction in OCD. First, studies using magnetic resonance spectroscopy are reviewed demonstrating altered glutamate concentrations in the caudate and anterior cingulate cortex of patients with OCD. Second, knockout mouse models, particularly the DLGAP3 and Slitrk5 knockout mouse models, display remarkably similar phenotypes of compulsive grooming behaviour associated with glutamate signalling dysfunction. Third, candidate gene studies have identified associations between variants in glutamate system genes and OCD, particularly for SLC1A1 which has been shown to be associated with OCD in five independent studies. This converging evidence for a role of glutamate in OCD has led to the development of novel treatment strategies involving glutamatergic compounds, particularly riluzole and memantine. We conclude the review by outlining a glutamate hypothesis for OCD, which we hope will inform further research into etiology and treatment for this severe neuropsychiatric condition.

A new concept for decoupling two coupled antenna elements in a broad band using a coupled resonator decoupling network (CRDN) is proposed for the first time. A synthesis and design theory of a CRDN is presented. Based on the admittance parameters of a given antenna array, a set of required rational functions and, consequently, the coupling matrix for a second-order decoupling network is obtained analytically. To prove the concept, two prototypes using microstrip resonators are designed and experimentally studied. Measurement results have demonstrated that an isolation improvement of more than 10 dB can be achieved within more than 15% bandwidth in both examples. The benefits of using a CRDN for different levels of isolation in a MIMO terminal are investigated through experiments and simulations. The results have shown that, as compared to the existing decoupling scheme using a lumped element, the proposed CRDN scheme can significantly increase the radiation efficiency, reduce the correlation, improve the channel capacity, and above all enhance the throughput of a MIMO terminal. The technique is general and can be applied to both symmetric and asymmetric arrays.Index Terms-Compact antenna array, decoupling network, multiple-input multiple-output (MIMO), mutual coupling, network synthesis.

A new decoupling scheme called dual-band coupled resonator decoupling network (CRDN) is presented. By properly designing the coupling coefficients between two pairs of coupled resonators, the network can effectively reduce the mutual couplings between two coupled dual-band antennas in two bands simultaneously. The new scheme is proved by a practical microstrip version of the device for two dual-band antennas working at 2.4 and 5.2 GHz frequency bands. A compact planar dualband CRDN consisting of a pair of dual-band open-loop square ring resonators is proposed. The measured scattering parameters of two coupled antennas with and without the dual-band CRDN in free space (FS) and with hand phantom demonstrate that the isolation between the two antennas in both the low and high bands can be improved from 8 to 10 dB, respectively, to below 20 dB while maintaining a good matching performance. The total efficiency and envelop correlation coefficient for the decoupled antennas show a significant improvement as compared to the coupled antenna case. The proposed dual-band CRDN scheme is easy to be implemented in an integrated device, and is very attractive for practical multiple input and multiple output (MIMO) applications.Index Terms-Compact antenna array, coupled resonators, decoupling network, dual-band, multiple input and multiple output (MIMO), mutual coupling.