Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level. An optical technique using dynamic light scattering (DLS) measurement is useful for point-ofcare testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements.
To find an early symptom of postprandial hyperlipidemia, we developed a technique to measure the change in triglyceride noninvasively. We examined the feasibility to measure the change in the triglyceride concentration as the change in the scattering coefficient of the blood. In an experiment, good correlation was obtained between the change in the triglyceride after a meal and the optical change. This suggested the feasibility of the noninvasive measurement of the triglyceride in blood.
For noninvasive measurement of the triglyceride in the blood, a technique was developed to estimate the scattering coefficient of a turbid medium from the backscattered intensity at two different points on the human body surface.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.