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Pre-ignition in internal combustion engines is an abnormal combustion phenomenon which often results in structural damage to the engine. It occurs when an ignition event takes place in the combustion chamber before the designed ignition time. In this work, a numerical study was done to investigate the pre-ignition with potential application to natural gas marine engines. This was done by simulating experiments of lube oil–induced ignition and subsequent combustion in a constant volume combustion chamber using an in-house version of the KIVA4-CFD code. Initial conditions of the chamber gases are obtained from the pre-burn process of a known composition of C2H2/oxidizer mixture. Natural gas was injected from a single-hole injector at an injection temperature and pressure of 300 K and 105 Pa, respectively. A rotating fan was modeled, as is in the experimental setup. Oil droplet of known size and velocity is injected into the constant volume combustion chamber. For accurate prediction of oil droplet ignition, the computational cells that contain the droplets are to be refined. Combustion calculations are then carried out on the refined grid. Ignition delay times of both lube oil and methane/air mixtures were calculated. Parametric studies were also conducted by varying droplet conditions, and their results are also presented.