Facile fabrication of a photoalignable film from a nonphotoreactive polymethacrylate with 4-oxybenzaldehyde side groups (1) and a monomeric 4-methoxyaniline (2) composite is investigated. A 1/2 composite film fabrication and the annealing process form photoalignable N-benzylideneaniline (NBA) side groups, while the linearly polarized (LP) 365 nm light exposure to the resultant film induces sufficient molecular reorientation of NBA side groups. Furthermore, patterned coating of 2 on a 1 film and subsequent LP light exposure generate a patterned molecular orientation combined with controlled birefringence.
A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridonones was synthesized and evaluated for positive inotropic activity, 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2- oxo-3-pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 micrograms/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a] pyridin-2-yl)-6-methyl-2(1H)-pyridinone (3u) was the most potent (i.v. ED50 11 micrograms/kg) in this series. E-1020 is presently under development for the treatment of congestive heart failure.
Adjusting
the free-surface condition facilely controls the in-plane
and out-of-plane orientations in liquid crystalline polymer (LCP)
films. Top coating with aromatic molecules onto LC polymethacrylate
films with N-benzylideneaniline (NBA) or 4-methoxybiphenyl
(MB) side groups (PNBAM or PMBM) and subsequent annealing generate
a random planar orientation while simultaneously removing the coated
aromatic molecules, whereas annealing noncoated films induces a homeotropic
orientation of the mesogenic side groups.
Additionally, irradiating a top-coated PNBAM film with linearly polarized
(LP) 365 nm light induces an in-plane molecular reorientation of the
NBA side
groups without changing the orientation in the homeotropically oriented
region. Changes in the surface topology of the LCP films due to the
reorientation processes are investigated in detail. Inkjet coating
with aromatic molecules and LP 365 nm light exposure precisely controls
the in-plane and out-of-plane
alignment pattern in a PNBAM film.
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