Objective To assess serum pyridinoline (Py) and deoxyplevels both in these patients and in 84 healthy control subjects. yridinoline (dPy), using a new high-performance liquid chromatography (HPLC) method, as a serum markerResults There was a significant correlation between the bone loss evaluated by radiography and the level of to determine the incidence of metastatic bone disease in an animal model and in the monitoring of patients serum Py in the animal model. Patients with bone metastases from RCC had higher values of Py and dPy with or without metastatic bone disease from prostate cancer and renal cell carcinoma (RCC).than patients without known metastatic bone disease. The serum Py level increased in two patients as metaPatients, materials and methods Female C3H/He mice (8-12 weeks old) received a subcutaneous injection static bone disease progressed. Similarly, in patients with prostate cancer, the mean level of serum Py and of tumour-cell suspensions of serially transplanted MBT tumours. The tumour cells induced osteolysis dPy was higher in patients with bone metastasis than in the control group, and also higher than that in associated with osteoclast proliferation and serum samples were evaluated for Py and dPy using HPLC.patients without metastases. The serum Py and dPy levels could also distinguish patients with metastatic The growth of the tumour macroscopically and histologically, and the extent of bone loss assessed by bone disease with and without a lytic component. Conclusion Measurements of serum Py appear to provide radiography, were compared with the serum Py and dPy level. In the clinical study, patients with or a good index of increased bone resorption induced by experimental tumours and in patients with bone metwithout bone metastases from RCC (24 patients) or prostate cancer (37 patients) were monitored using astases from RCC and prostate cancer. Keywords Pyridinoline, bone metastases, prostate the same techniques and the number and extent of bone metastases compared with serum Py and dPy cancer, kidney cancer Whereas local osteolysis has been induced successfully
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.