A questionnaire study was done in order to clarify the risk ratios on the mortality of malignancy and the characteristics of malignancies in dialysis patients. The risk ratios were 4.2 times in males and 7.5 times in females greater than those among the age adjusted general population respectively. The average interval from the first dialysis to the clinical onset of malignant disease was 12 months. About a half of the patients died within 3 months. Frequencies of death in colon cancer, especially rectum, uterus and liver were higher in dialysis patients. Dialysis patients died of malignancies belonged to the older group of the dialysis patient population, however they were younger comparing with those died of malignancies in the general population.
In order to assess the toxicity of the potting material of dialyzers,the effect of extracts of potting materials on DNA synthesis of PHA-activated human lymphocytes was studied.DNA synthesis of lymphocytes was inhibited by addition of ethanol and serum extracts of one type of potting material to the culture.The saline and serum extracts of another type of potting material also caused inhibition of DNA synthesis.The extract of the gamma ray-irradiated potting material of the latter type showed a weaker inhibitory effect than that of the non-irradiated material.The inhibition induced by the extract of an ethylene oxide gas treated material of the former type was slightly stronger than that induced by the extract of the nontreated material.The inhibitory factors originating in the potting materials could be at least part of the cause of the immunosuppressive state of dialysis patients.
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