Proteins in hyperthermophiles exhibit extremely high thermal stability unlike general proteins. These thermostable proteins are stabilized by weak molecular interactions such as hydrogen bonding, charge interactions and van der Waals (vdW) interactions, along with the hydrophobic effect. An in-depth understanding of the stabilization mechanisms will enable us to rationally design artificial molecules with very high thermal stability. Here we show thermally stable supramolecular assemblies composed of six identical amphiphilic molecules having an indented hydrophobic surface, held together by weak intermolecular interactions (vdW and cation-π interactions) and the hydrophobic effect in water. The disassembly temperature of one of the assemblies is over 150°C, which is higher than that of the most hyperthermophilic protein reported to date (PhCutA1). Study of the relationship between the structure of the components and the stability of the assemblies indicates that the hyperthermostability is achieved only if all the weak interactions and the hydrophobic effect work cooperatively.
We investigated the self-assembly process of a Pd 4 L 8 double-walled square (DWS) from [PdPy* 4 ] 2+ (Py*: 3-chloropyridine used as the leaving ligand on the Pd II center) and an organic ditopic ligand by QASAP (quantitative analysis of selfassembly process). DWS is assembled mainly through three pathways. Within 5 minutes of the self-assembly, all of the substrates, the metal source and the organic ditopic ligand, were completely consumed and converted into primary intermediates. In 2 h, the primary intermediates afforded 30 % of DWS, 200-nm-sized large intermediates, and a relatively stable transient intermediate. This stable intermediate was characterized as a kinetically trapped Pd 3 L 6 double-walled triangle (DWT) by [a]
We have developed effective reaction conditions for the Suzuki cross-coupling of chlorinated hexaphenylbenzene derivatives. A chloro group on a hexaphenylbenzene framework exhibits a low reactivity to Suzuki cross-coupling, and only nickel catalysts bearing alkyl-substituted phosphine ligands achieved the coupling. With this as a key step, we succeeded in the selective preparation of a C
2v
-symmetric hexaphenylbenzene derivative containing two kinds of aryl group.
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