nitriles nitriles (acyclic compounds) P 0350
-080Aldol and Michael Reactions of Nitriles Catalyzed by Cyclopentadienylruthenium Enolate Complexes.-The new Ru complexes shown in the scheme are found to be highly effective catalysts for aldol and Michael reactions of nitriles. -(MURAHASHI
prepared diazomethane in ether. The reaction mixture was concentrated and chromatographed on silica gel to yield the desired methyl carboxylate.Preparation and Oxidation of (±)-5. A sample of (±)-5 was prepared from (±)-4g (1.14 g) by treatment with m-chloroperbenzoic acid (1.65 g excess) in CHC13 (50 mL) at 0-5 °C over the weekend. The CHC13 solution was washed with NaHC03, dried, and concentrated. The JV-oxide was purified by chromatography on silica gel; NMR (CDC13, 220 MHz) b 1.59 (d, 3 ), 2.14 (s, 3 H), 6.39 (q, 1 ), 7.14-7.43 (m, 3 ), 8.18 (d, 1 H); mass spectrum 1980, 21, 3335.
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