▶ Fig. 2 Endoscopic ultrasound using a 20-MHz miniature probe showing: a a high echoic submucosal layer between the tumor and the muscularis during insufflation; b when the cecum contracted while still under water, the muscularis becoming circumferentially recessed and the submucosa becoming thicker, with the tumor appearing to float on the submucosa. c On underwater endoscopic view, the tumor was transformed from a sessile tumor to a floating subpedunculated tumor.
A 66-year-old man diagnosed with immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) with diffuse intrahepatic bile duct stenosis and elevated serum IgG4 levels was referred for a further examination because of elevated serum CA19-9 levels despite treatment with corticosteroids. An umbilical nodule was found on a physical examination and a biopsy showed adenocarcinoma. Although several imaging studies revealed no changes from prior studies, bile cytology collected by endoscopic retrograde cholangiopancreatography showed adenocarcinoma. Consequently, the patient was diagnosed with cholangiocarcinoma resembling IgG4-SC after detecting an umbilical metastasis, also known as Sister Mary Joseph's nodule.
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