The purpose of this study was to investigate the minimum effective dose of recombinant canine interferon-gamma (rCaIFN-gamma) for the treatment of dogs with atopic dermatitis (AD). Thirty-four dogs with AD from 17 animal hospitals in Japan were administered half or one-fifth of the approved rCaIFN-gamma dose of 10 000 units/kg, three times a week for 4 weeks, followed by once weekly for an additional 4 weeks. Pruritus, excoriation, erythema and alopecia were evaluated and scored by the investigators on weeks 2, 4, 6, 8 and 12. The efficacy rate (number of excellent cases + number of good cases/total number of cases) at week 8 in the 2000 units/kg group was 36.4% for pruritus, 36.4% for excoriation, 45.5% for erythema and 36.4% for alopecia. In contrast, in the 5000 units/kg group, the efficacy rate was 64.3% for pruritus, 57.1% for excoriation, 78.6% for erythema and 78.6% for alopecia. The efficacy rate of the 5000 units/kg group was high for all signs evaluated and comparable to that of the 10 000 units/kg group reported in a previous study. The results of this study showed that 2000 units/kg of rCaIFN-gamma is less effective than 5000 units/kg to treat dogs with AD, and the efficacy of the 5000 units/kg dose is comparable to that of 10 000 units/kg at week 8.
All the premolars and molars of 14 cats under medical treatment for gingivo-stomatitis and suffering severe pain during eating were extracted. Thereafter macroscopic oral inflammation disappeared in 5 (35.7%) of the cats and pain during eating in 6 (42.9%). The overall-symptom rate of improvement for macroscopic faucitis was 71.4% (10 of 14); the corresponding rate for eating pain was 64.3% (9 of 14). Cats suffering from severe faucitis before treatment and those infected with FeLV and/or FIV tended to respond poorly to the therapy. 3-2-3 Onda-cho, Ube 755-0023, Japan TEL 0836-34-2861 FAX 0836-22-3341 J. Jpn. Vet. Med. Assoc., 55, 95•`98 (2002)
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