Based on the current available evidence, pregabalin is not recommended for use in benzodiazepine discontinuation, as the majority of studies did not find a significant difference in benzodiazepine discontinuation rates between pregabalin and comparatory groups despite an improvement in withdrawal and anxiety symptoms.
Multi-drug-resistant (MDR) Acinetobacter baumannii is identified by the Center for Disease Control and Prevention (CDC) as an urgent threat to public health, requiring the development of novel treatment options. 1,2 A. baumannii is a significant contributor to serious nosocomial infections including hospital-acquired/ventilator-associated bacterial pneumonia (HABP/VABP), bloodstream infections (BSI), complicated urinary tract infections (cUTI), and wound infections.Mortality rates due to MDR A. baumannii have been estimated between 40% and 60%, with some studies showing rates of up to 75% in critically ill patients. 3 From 2019 to 2020, the CDC reported a 35% increase in carbapenem-resistant Acinetobacter spp. overall and a 78% increase in hospital-associated carbapenem-resistant Acinetobacter baumannii (CRAB) infections, which may be a consequence of increased intensive care unit (ICU) admission and length of stay (LOS) attributed to the COVID-19 pandemic. 4 Antimicrobial resistance, including resistance to all standard-ofcare antibiotics, is a feature of A. baumannii secondary to the acquisition of both intrinsic and acquired resistance phenotypes. 3,5 In
This work compares carbapenem-resistant
Enterobacterales
(CRE) infections using patient, clinical, and treatment variables to understand which characteristics are associated with the highest risk of clinical failure. Knowing which risk factors are associated with CRE infection failure can provide clinicians better prognostic and targeted interventions.
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