NIR spectroscopy I Glucose determination I Neural networks I Multivariate calibration NIR spectroscopy was used for the non-invasive determination of blood glucose for different test persons. For this purpose spectra were obtained using a spectrometer with fibre-optical measuring-head scanning from 900 nm to 1200 nm. The results of different methods of multivariate calibration are presented and discussed.NIR-Spektroskopie wurde eingesetzt, um nichtinvasive Blutzuckerbestimmungen an verschiedenen Probanden durchzuführen. Dazu wurden Spektren im Bereich von 900 nm bis 1200 nm mit einem Spektrométer mit faser-optischem Meßkopf in diffuser Reflexion aufgenommen. Die Ergebnisse der Auswertung mit verschiedenen Methoden der multivariaten Kalibration werden vorgestellt und diskutiert.
Modern strategies in the treatment of Diabetes mellitus require frequent blood glucose tests. Near-infrared spectroscopy [NIR] is considered to be a method for non-invasive blood glucose testing. The present study evaluated the long-term accuracy and stability of the method. Spectra of 10 patients were recorded. An individual calibration models were calculated for each patient from spectra which were recorded at the beginning of the investigation. These models were then applied to calculate blood glucose values from spectra which were recorded 84 to 169 days later. The long-term accuracy and stability of the calibration models expressed as root mean squared error of prediction [RMSP] varied from 3.1 to 35.9 mmol/l and the error grid analysis [EGA] from 13 to 92% clinically acceptable values in zones A and B. The results of the investigation indicate that long-term monitoring of blood glocose by means of NIR-spectroscopy and individual calibration models over a period of 3 to 4 months is basically possible once long-term stability of the method will be improved. Further technological progress and a better understanding of the underlying physiological processes is necessary to achieve a level of accuracy, reliability and stability of the method as required for clinical application.
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