Context: Peptic ulcer is a common disorder of the stomach and duodenum. Bangladesh is a developing country with a very high point prevalence of duodenal ulcer disease (11.9%) and a H. pylori prevalence of more than 90% in asymptomatic adults and 80% in children at the age of 5 years. The multifactorial pathogenesis of peptic ulcers is secretion of gastric acid. The main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole). However, nowadays, gastric ulcer therapy faces a major drawback because most of the drugs currently available in the market show limited efficacy against gastric diseases and are often associated with severe side effects. Thus, there is an urgent need to identify more effective and safe antiulcer agents. In this context, the use of medicinal plants for the prevention and treatment of different pathologies is in continuous expansion worldwide. From the ancient time, various plants were used in traditional medicine with reputation as efficacious remedies. The list of plant derived modern medicine is very long now. About 33% of the drugs produced in the developed countries are derived from plants. Trigonella foenum-graecum (Fenugreek, Methi) is one of them used in many parts of world. Preliminary study on animal showed that Trigonella foenum-graecum seed has significant gastro-protective effect. A study was carried out to demonstrate the gastro-protective effect of aqueous extract and ethanolic extract of Trigonella foenum-graecum seed (Fenugreek, Methi) and omeprazole on ethanol induced gastric ulcer in experimental rats. Material and Methods: The present study was performed on 24 (twenty four) rats which were divided randomly into 4 groups each having 6 rats in the Pharmacology Department of Dhaka Medical college, Dhaka. 1 ml of absolute ethanol (5ml/kg body wt.) was orally administered to all groups by gastric intubations to induce gastric ulcer in all groups except normal control. Omeprazole suspension (20mg/kg body wt) was used as synthetic anti ulcer drug in study. Aqueous and ethanolic extract of Trigonella foenum-graecum seed(500mg/kg body wt) were used respectively orally. Histopathological analysis was carried out to evaluate the gastroprotective activity of aqueous and ethanolic extract of Trigonella foenum-graecum seed and omeprazole on ethanol induced gastric ulcer in experimental rats. Result: Pretreatment with aqueous and ethanolic extract of Trigonella foenum-graecum seed (500mg/kg/body wt) showed very significant prevention in ethanol induced gastric ulcer. Results of the study showed that in case of ethanol treated rats gross examination showed a large amount of haemorrhagic lesions confined mostly in the gastric corpus. Histologically lesion involved about two-third of the mucosa layer and exfoliation of the mucosal cells was detected. Meanwhile, red blood cells were present in the gastric mucosa and edematous submucosa was discovered. However aqueous and ethanolic extract of Trigonella foenum-graecum seed significantly reduced the haemorrhagic lesions, tissue proliferation, infiltration of cells and sloughing induced by ethanol. This prevention was statistically very significant (P<0.001). Conclusion: The aqueous and ethanol extracts of Trigonella foenum-graecum seed and omeprazole possess gastro protective properties. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 67-75
Background: The misuse and overuse of antibiotics can lead to antibiotic resistance. Thus, it is important to have adequate knowledge and attitude toward antibiotic use and resistance for all specially the medical students who are the future healthcare practitioners. The aim of this study was to assess the knowledge and attitude toward antibiotic use and resistance among 4th year students of Shaheed Monsur Ali medical college. Material Methods: This cross-sectional study was conducted in Shaheed Monsur Ali medical college, Dhaka, Bangladesh from October 2022 to December 2022. A structured questionnaire was administered to 126 randomly selected undergraduate medical students. Results: In our study, the percentage of male and female was same. Majority of the participants (55.56%) always get a prescription before starting antibiotics. Most of the participants (60.32%) never stop taking the prescribed antibiotics after their symptoms improved. Majority of the participants (54.76%) sometimes completed the course of the prescribed antibiotic treatment. In our study, majority of the participants (54.76%) sometimes take the correct dose of their antibiotics at the right time for the full duration. In this study, majority of the participants (47.62%) never save the remaining antibiotics for next time they get sick. Majority of the participants (73.02%) sometimes give leftover medication to friends or family if they get sick. For cough or sore throat, majority of the participants (48.41%) sometimes prefer taking an antibiotic. Most of the participants (69.05%) never buy the same antibiotics if they are sick that helped them get better when they had the same symptoms before. Most of the participants (96.03%) always check the expiry date of the antibiotic before using it. Knowledge level of antibiotic in majority of the participants (47.62%) was very good. Knowledge level of antibiotic resistance in majority of the participants (54.76%) was very good. Attitude level of antibiotic usage in majority of the participants (34.13%) was average, followed by 32.54% had bad, 32.54% good attitude level. Conclusion: From the findings of the study, it can be concluded though the knowledge level of the medical students is adequate, they are not careful about the usage of antibiotics and often misuse it. The students tend to not follow the rules of the usage guideline of antibiotics which ultimately results in antibiotic resistance. They should be more conscious to follow the guidelines of antibiotic usage.
Context: Use of herbal medicine throughout the world is increasing. Plants still remaining the primary source of supply of many important drugs used in modem medicine. Spinacia Oleracea i,e spinach leaves contain more number of anti-inflammatory phytochemcicals such as carbohydratie, tanins and phenolic compounds, saponins, flavinoids and steroid. Better collagenation seen under the influence of the flavinoids, phenolic compound and saponins which is responsible for the free radical scavenging activity and are believed to be some of the most important component for wound healing and antioxident activity. Spinacia Oleracea scavenges free oxygen redicals and increases the catalase level in granulation tissue. Plants still remaining the primary source of supply of many important drugs used in modem medicine. Considering its medicinal value and availability in our country this study was undertaken to evaluate the antiinflammatory effect of the Spinacia Oleracea leaf extract in rat models. Material and Methods: The experiments were carried out on 30 (thirty) Swiss male albino rats. They were collected from the ICDDRB, Dhaka. The rats were of male weighing between 150- 200gm which were divided randomly into 5 groups each having 6 rats. Groups were labeled as group-I, group-II, group-III, group-IV and group-V. The anti inflammatory effect of Spinacia Oleracea leaf extract in experiment rat were evaluated and compared with the anti inflammatory effects of aspirin and hydrocortisone. The study was prospective experimental type and was conducted in the department of Pharmacology, Dhaka Medical College, Dhaka, from July 2011 to June 2012. Result : Administration of mathanolic extract and water extract of Spinacia Oleracea leaf at a dose of 200mg/kg body weight orally produced a significant (P<0.05) anti-inflammatory effect, and the percentage of inhibition of oedema formation was 28.75% and 40.79% respectively. There were highly significant (P<0.05) percentage of inhibition of oedema formation was observed in aspirin (40.52%) and in hydrocortisone (47.71%). Conclusion: Spinacia Oleracea leaf extract, possess significant anti-inflammatory activity in rats. J Dhaka Medical College, Vol. 27, No.1, April, 2018, Page 88-93
Background/context: Dietary diversity (DD) is universally recognized as a key component of healthy diets. Healthy diet is one of the most important determinants that can influence nutritional status of women of reproductive age. Materials and Methods: This cross sectional study was conducted in Shitpara village of Sreepur Upazila under Gazipur district during February to June 2013 to assess the dietary diversity and nutritional status of women of reproductive age. Convenient sampling technique was adopted to select 181 women. Interview schedule & checklist used as research instrument. Results: The mean(+/-s.d.)age of the respondents was 27.45+/-9.38 years, 133(80%) of them were married and 176(97.2%) are literate. Mean family size was 5.34+/- 2.386 persons and mean family income was 9611.05 Taka per month. Among 133 married women, 68(51%) have 2 or less than two children. Their mean(+/-s.d.) dietary diversity score was 5.13+/- 1.19 and majority 149(82%) of them having medium dietary diversity tercile (4-6). All of them ate carbohydrate types of food, 174(96.1%) protein rich foods & 83(45.9%) vit.A rich vegetables & fruits. Their mean BMI was 22.35 +/- 3.71 kg/ m2. Majority 118 (65%) of them having normal BMI and 22(12%) are under weight. Only 6(3%) of them are obese. Thoughdietary diversity was medium (4-6); relationship between dietary diversity and nutritional status could not be established. Conclusion:The qualitative measurement of dietary diversity is not sufficient enough to identify women at risk of under- or over nutrition. J Dhaka Medical College, Vol. 27, No.1, April, 2018, Page 36-40
Aims: The present study was performed to investigate the hypolipidaemic effect of natural honey in hyperlipidaemic rats. We also compared the hypolipidaemic effects of natural honey with a standard known hypolipidacmic agent, atorvastatin.Methods: At first the rats (n=42), were randomly divided into six groups. Each group composed of seven rats. Group A control group received normal diet, distilled water for 10 days. Group B hyperlipidemic group received normal diet olive oil (1.5inl) with cholesterol daily for 10 days. Group C received normal diet, distilled water. D, E & F. On the 11th day of experiment the final body weight was measured & blood was collected by cardiac puncture for the study of lipid profile.Result: Only cholesterol fed Group B and C rats gained body weights. Natural honey and atorvastatin treated group of rats. Group D, E, F lost body weights. These changes between the initial and final body weight were statistically significant (p<0.05). Regarding the lipid levels, it was observed that (a) there as statistically significant rise of serum TCI., LDL & TG levels in group B compared to that of group A (p <0.001 in each parameter), b the serum TCL is significantly decreased in group B (p<0.05), and group F (p<0.01) in the comparison to groups; the value also decreased in group D but the decrease was slightly significant (C) the serum LDL level significantly reduced in group D, E & F compared to group C; but the maximum effect comparison to group C; the value also decreased in group D but the decreased was slightly significant. (C) the serum LDL level significantly reduced in group D, E & F compared to group C, but maximum effect was observed in group E & F (p <0.001). (d) No significant change of serum HDL was observed in Group D but slightly significantly increased in group E and group F (p <0.05) compared to group C. (e) The serum TG level reduced significantly (p <0.001) in group D. E and F compared to group C. Thus study showed natural honey reduced TCL, LDL & TG and slightly increase HDL and atorvastatin reduce TCL, LDL & TG. But atorvastatin have some side effect on the other hand natural honey have no side effect.Conclusion: The result and observation of the present study provide a rationale for use of natural honey in the development of a new herbal medicine much needed for the reduction of serum lipid levels (TCL, TO, LDL). Atorvastatin also lower TCL, LDL & TO. Thus it could he useful in hyperlipidaemic conditions. But before establishing natural honey as a therapeutically effective hypolipideamic agent, further studies should be carried out to determine the active principles responsible for hypolipidaemic effect and its cellular mechanism of action.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 94-102
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