Artabotrys species which belongs to Annonaceae family are pleasant smelling and it is attributed to the presence of mono and sesquiterpenoids present in the essential oil of the plant. The objective of the present work is to review the chemical composition of the essential oils reported from twenty different Artabotrys species from various parts of the world. In the various Artabotrys species, the major compounds are monoterpene and sesquiterpene hydrocarbons and oxygenated sesquiterpenes. The frequently and most commonly identified constituents are β-caryophyllene, caryophyllene oxide, 3-Carene, cyperene, cyperenone and 1,5-epoxy-salvial4(14)-ene. Other constituents seems to be more specific to the respective Artabotrys species.
Owing to the excellent properties of rhodanine based molecules are one of the bioactive heterocyclic compounds and are used in various applications in industry, biochemistry and coordination chemistry. Rhodanine and their derivatives have broad industrial applications and widely used as intermediates in the syntheses of dyes, extreme-pressure lubricants and as brightening additives in silver electroplating. They also exhibit antioxidant properties as well as pharmacological [1] and biological activities including antibacterial [2], antiviral [3] and antidiabetical [4] properties. Due to their strong ability in donating electrons to metal ions, make them strong ligands in coordination compounds [5]. A rapid development in rhodanine chemistry was observed because of their use as inhibitors for protein mannosyl transferase-1 [6], phosphodiesterase-4 [7], protease [8], JSP-1 [9], UDP-N-acetylmuramate-L-alanine ligase [10], antimalerials [11], HIV-1 integrase [12-15] and β-lactamase [16]. Rhodanine nucleus containing commercial drug Epalrestat is used as aldose reductase inhibitor in some Asian countries [17,18]. In our earlier study reported that the in vitro cytotoxicity of a series of rhodanines found that 3-α-carboxy ethyl rhodanine was found to be more active against HeLa cell lines (IC 50 = 10 µg/mL). The present work, we have reported the single crystal XRD of the active molecule 3-α-carboxy ethyl rhodanine for the first time. Further we have carried out in silico molecular docking studies against human cervical cancer oncoproteins HPV 16 E2 and a tyrosine kinase
Strobilanthes ciliatus was used in the traditional medicine to treat central nervous system problems and cancer. This study aims to investigate the cytotoxic and inhibitory activity of acetylcholinesterase in extracts and isolated compounds of S. ciliatus. Chemical investigation of S. ciliatus led to isolation of two compounds. The isolated compounds were characterized by spectral studies like (IR, UV-Vis, MS and NMR) as lupeol and stigmasterol. The extracts and isolated compound have been evaluated for AChE inhibitory activity by Ellman’s method and cytotoxicity on Hela and K562 cell lines by MTT method. The extracts and the isolated compounds showed moderate activities against acetylecholinesterase enzyme and HeLa and K562 cell lines.
NiO nanoparticle has been synthesized by a greener method using Polianthes tuberosa plant extract. The nanoparticle was characterized by UV-Visible, FT-IR, XRD and SEM instrumental techniques. The absorption band appeared at 269 nm in UV-Visible spectrum supported the formation of NiO nanoparticles. The IR spectrum analysis showed a broad band at 554 cm-1 characteristics of NiO nanoparticles. From the XRD results, the crystalline size and shape of NiO nanoparticles was determined to be 3.23 nm with a face centered cubic crystal. The NiO nanoparticles has been distributed well. From SEM results, the synthesized NiO sample has particle size between 5 and 11 nm range. The cytotoxic results showed significant activity of the synthesized NiO nanoparticles against MM2 and HeLa cells.
Objective: Spiro compounds are present in nature, endowed with deep biological activities. Heterocyclic compounds with a pyrrolidine scaffold are one of the paradigms of organic chemistry that exhibits a wide variety of properties and biological functions. Based on these, seven dispiropyrrolidines have been accomplished by [3+2] cycloaddition reaction from acenaphthenequinone and sarcosine with several dipolaro files such as substituted 5-benzylidene-2-thioxothiazolidin-4-ones.
Methods: Cycloadducts 4a-g were prepared by conventional method and the structures of the compounds 4a-g were completely characterized by infrared, 1H, 13C nuclear magnetic resonance spectral data, and elemental analysis. The cytotoxic activity of the synthesized compounds was carried out by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay.
Results: The dispiropyrrolidines 4a-g were showed a moderate-to-good cytotoxic activity against human cervical cancer lines. Among all the synthesized compounds, 4d was found to be more potent with human cervical cancer line with an half maximal inhibitory concentration (IC50) value of 5.5 μM.
Conclusion: The synthesized compound 4d found to be an excellent activity which is nearly closed to reference drug gemcitabine with an IC50 value of 4.6 μM.
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