Constipation and associated health issues like acid reflux, malnutrition were commonly observed in regions with water availability limitations. Although some of the products available in the market address this issue, there is limited research on development of such products which will be able to solve multiple associated issues. Sterculia gum, a natural product known for water retention and associated properties in traditional systems of medicine. Despite this, research and therapeutic applications of this product are in infancy. This study was aimed to develop laxative oral granules of sterculia gum with some other therapeutically and nutraceutical active ingredients for multiple applications as bulk laxative, demulcent, water retention agent, diarrhea and appetite controller in the management of obesity. Sterculia gum, magnesium trisilicate, dried magnesium sulphate, heavy kaolin and excipients characterization and product development was carried out with developed in house formulation technology. Developed formulation was evaluated for various formulation based evaluation parameters. Desirable pH range of 4.3 to 6.9 was observed indicating reduction in acidic properties of sterculia gum; good swelling index was observed 240ml/3gm. Identification tests and assay of active ingredients were carried and found to be within specified limit range. Developed formulation showed desirable stability of 12 months indicating good shelf life of product. Study results revealed developed formulation can be further investigated in clinical studies and might be served as novel dosage form for therapeutic applications in habitual constipation for multiple therapeutic targets with single product.
Chronic kidney diseases (CKD) are an important public health concern worldwide. In developed as well in less-developed countries, prevalence of CKD is increasing day by day. Large numbers of people are affected by cost of care, dialysis and transplantation treatment strategies and lack of awareness in rural areas and implementation of treatment strategies. Primordial prevention of CKD can be achieved through implementation of measures to ensure healthy development by working on new treatment strategies, accepting new processes of prevention and covering gaps found during the previous data created. This review work is aimed to compile in depth literature on CKD; majorly relationship between acute kidney injuries (AKI), CKD and end stage renal disease (ESRD) causes and different stages of CKD, prevalence or epidemiology and global current status. Diagnosis parameters, current treatment strategies along with traditional medicines and new pipeline drugs on CKD are described in detail for prevention and treatment of CKD, along with gap analysis.
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