Clustering As a result of the rapid development in cloud computing, it & fundamental to investigate the performance of extraordinary Hadoop MapReduce purposes and to realize the performance bottleneck in a cloud cluster that contributes to higher or diminish performance. It is usually primary to research the underlying hardware in cloud cluster servers to permit the optimization of program and hardware to achieve the highest performance feasible. Hadoop is founded on MapReduce, which is among the most popular programming items for huge knowledge analysis in a parallel computing environment. In this paper, we reward a particular efficiency analysis, characterization, and evaluation of Hadoop MapReduce Word Count utility. The main aim of this paper is to give implements of Hadoop map-reduce programming by giving a hands-on experience in developing Hadoop based Word-Count and Apriori application. Word count problem using Hadoop Map Reduce framework. The Apriori Algorithm has been used for finding frequent item set using Map Reduce framework.
Background Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder caused due to pathogenic variants in the SUMF1 gene. The SUMF1 gene encodes for formylglycine generating enzyme (FGE) that is involved in the catalytic activation of the family of sulfatases. The affected patients present with a wide spectrum of clinical features including multi-organ involvement. To date, almost 140 cases of MSD have been reported worldwide, with only four cases reported from India. The present study describes two cases of late infantile form of MSD from India and the identification of a novel missense variant in the SUMF1 gene. Case presentation In case 1, a male child presented to us at the age of 6 years. The remarkable presenting features included ichthyosis, presence of irritability, poor social response, thinning of corpus callosum on MRI and, speech regression. Clinical suspicion of MSD was confirmed by enzyme analysis of two sulfatase enzymes followed by gene sequencing. We identified a novel missense variant c.860A > T (p.Asn287Ile) in exon 7 of the SUMF1 gene. In case 2, a two and a half years male child presented with ichthyosis, leukodystrophy and facial dysmorphism. We performed an enzyme assay for two sulfatases, which showed significantly reduced activities thereby confirming MSD diagnosis. Conclusion Overall, present study has added to the existing data on MSD from India. Based on the computational analysis, the novel variant c.860A > T identified in this study is likely to be associated with a milder phenotype and prolonged survival.
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