In this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper “The within-host viral kinetics of SARS-CoV-2” published in (Math. Biosci. Eng. 17(4):2853–2861, 2020). Important properties of the model, like nonnegativity of solutions and their boundedness, are established. Also, we have calculated the basic reproduction number which is an important parameter in the infection models. From stability analysis of the model, it is found that stability of the biologically feasible steady states are determined by the basic reproduction number $(\chi _{0})$
(
χ
0
)
. Numerical simulations are done in order to substantiate analytical results. A biological implication from this study is that a COVID-19 patient with less than one basic reproduction ratio can automatically recover from the infection.
In this paper, the dynamical behavior of a mathematical model of cancer including tumor cells, immune cells, and normal cells is investigated when a delay term is induced. Though the model was originally proposed by De Pillis et al. (Math. Comput. Model. 37:1221–1244, 2003), to make the model more realistic, we have added a delay term into the model, and it has incorporated novelty in our present work. The stability of existing equilibrium points in the delay-induced system is studied in detail. Global stability conditions of the tumor-free equilibrium point have been found. It is shown that due to this delay effect, the coexisting equilibrium point may lose its stability through a Hopf bifurcation. The implicit function theorem is applied to characterize a complex function in a neighborhood of delay terms. Additionally, the presence of Hopf bifurcation is demonstrated when the transversality conditions are satisfied. The length of delay for which the solutions preserve the stability of the limit cycle is estimated. Finally, through a series of numerical simulations, the theoretical results are formally examined.
The prime objective of the current study is to propose a novel mathematical framework under the fractional-order derivative, which describes the complex within-host behavior of SARS-CoV-2 by taking into account the effects of memory and carrier. To do this, we formulate a mathematical model of SARS-CoV-2 under the Caputo fractional-order derivative. We derived the conditions for the existence of equilibria of the model and computed the basic reproduction number R0. We used mathematical analysis to establish the proposed model’s local and global stability results. Some numerical resolutions of our theoretical results are presented. The main result of this study is that as the fractional derivative order increases, the approach of the solution to the equilibrium points becomes faster. It is also observed that the value of R0 increases as the value of β and πv increases.
In this study, we discuss a cancer model considering discrete time-delay in tumor-immune interaction and stimulation processes. This study aims to analyze and observe the dynamics of the model along with variation of vital parameters and the delay effect on anti-tumor immune responses. We obtain sufficient conditions for the existence of equilibrium points and their stability. Existence of Hopf bifurcation at co-axial equilibrium is investigated. The stability of bifurcating periodic solutions is discussed, and the time length for which the solutions preserve the stability is estimated. Furthermore, we have derived the conditions for the direction of bifurcating periodic solutions. Theoretically, it was observed that the system undergoes different states if we vary the system’s parameters. Some numerical simulations are presented to verify the obtained mathematical results.
This paper mainly targets to deduce an optimal treatment strategy for combined antiretroviral drugs, which can maximize healthy CD4[Formula: see text] T cells level with minimum side effects and cost. For this purpose, we consider a within-host treatment model for the HIV infection with two controls incorporating full logistic proliferation of healthy CD4[Formula: see text] T cells, cure rate and fusion effect. These two controls represent the effects of reverse transcriptase inhibitors (RTIs) and protease inhibitors (PIs), respectively. The model analysis begins with proving different basic properties like non-negativity, boundedness of the model solutions and calculation of the basic reproduction number of the model under consideration. Then, stability results are obtained for HIV infection-free equilibrium point and also, a critical efficacy for the combined therapies is calculated. After that, the optimal control problem is proposed and solved numerically using a forward–backward iterative method. Finally, we obtain an optimal treatment strategy that can maximize healthy CD4[Formula: see text] T cells count and control the viral load, and HIV-infected CD4[Formula: see text] T cells count to an undetectable level resulting in improved health conditions of infected individuals.
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