The cosmetics market in India is mounting about 20 percent annually, twice as fast as that of the US and European markets. Although the cosmetic regulations in India are complex and time-consuming, which are needful for pre & post-marketing approvals. It is therefore important for a cosmetic manufacturers, distributers and importers to
Cloves are widely used in dental care, and are effective against a large number of bacteria. The main component of clove oil is eugenol, with β-caryophyllene and eugenyl acetate. The review of published results reveals a great opportunity to treat periodontal disease. The purpose of this study is to compare the bud, leaf and stem essential oil compositions from S. aromaticum and then to evaluate the correlation of the results with anatomic and geographical origins of the essential oil. Many commercial essential oils isolated from bud, leaf and stem were used in this work. The oils were analyzed by GC and then constituents were identified from the whole. The major constituent in oils was eugenol, with increasing percentages from bud (72.08 - 82.36%) to leaf (75.04 - 83.58%) and stem (87.52 - 96.65%). In the clove bud essential oil eugenyl acetate is the second major component (8.6 - 21.3%) while detected in considerably lower amount in the leaf (0 - 1.45%) and stem (0.07 - 2.53%). In leaf essential oil, the second main compounds were β-caryophyllene (11.65 - 19.53%) and α-humulene (1.38 - 2.17%), less represented in bud essential oils (2.76 - 8.64% and 0.34 - 1.04% respectively) and in stem essential oils (1.66 - 9.7% and 0.22 - 1.31% respectively). For each plant material, variation in the percentage of the main constituents was observed according to the sample geographic origin.
High efficiency and less run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, a new separation technique, ultra-performance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method is developed for the determination of nabumetone in tablet dosage form. In this work, a new isocratic chromatographic method is developed. The newly developed method is applicable for assay determination of the active pharmaceutical ingredient. The chromatographic separation is achieved on a Waters Acquity BEH column (100 mm, i.d., 2.1 mm, 1.7 µm) within a short runtime of 2 min using a mobile phase of 5 mM ammonium acetate-acetonitrile (25:75, v/v), at a flow rate of 0.3 mL/min at an ambient temperature. Quantification is achieved with photodiode array detection at 230 nm, over the concentration range of 0.05-26 µg/mL. Forced degradation studies are also performed for nabumetone bulk drug samples to demonstrate the stability-indicating power of the UPLC method. Comparison of system performance with conventional high-performance liquid chromatography is made with respect to analysis time, efficiency, and sensitivity. The method is validated according to the ICH guidelines and is applied successfully for the determination of nabumetone in tablets.
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